Reactome | 8,9-EET is hydrolysed to 8.9-DHET by EPHX2

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8,9-EET is hydrolysed to 8.9-DHET by EPHX2 Show undefined attributes

authored	[InstanceEdit:2142839] Williams, MG, 2012-02-24
catalystActivity	[CatalystActivity:2161846] epoxide hydrolase activity of EPHX2 dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9915999] D'Eustachio, Peter, 2024-07-19
crossReference	[DatabaseIdentifier:12668397] RHEA:44049 [DatabaseIdentifier:9915979] RHEA:44049
dbId	9915968
displayName	8,9-EET is hydrolysed to 8.9-DHET by EPHX2
edited	[InstanceEdit:2142839] Williams, MG, 2012-02-24
eventOf	[Pathway:R-HSA-2142670] Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) - Homo sapiens
input	[SimpleEntity:R-ALL-2142662] 8,9-EET [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2162029] Characterization and identification of cytochrome P450 metabolites of arachidonic acid released by human peritoneal macrophages obtained from the pouch of Douglas [LiteratureReference:2162016] Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	8,9-EET is hydrolysed to 8.9-DHET by EPHX2 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O => 8,9-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate
orthologousEvent	[Reaction:R-GGA-9915968] 8,9-EET is hydrolysed to 8.9-DHET by EPHX2 - Gallus gallus [Reaction:R-XTR-9915968] 8,9-EET is hydrolysed to 8.9-DHET by EPHX2 - Xenopus tropicalis [Reaction:R-DRE-9915968] 8,9-EET is hydrolysed to 8.9-DHET by EPHX2 - Danio rerio [Reaction:R-SSC-9915968] 8,9-EET is hydrolysed to 8.9-DHET by EPHX2 - Sus scrofa [Reaction:R-BTA-9915968] 8,9-EET is hydrolysed to 8.9-DHET by EPHX2 - Bos taurus [Reaction:R-CFA-9915968] 8,9-EET is hydrolysed to 8.9-DHET by EPHX2 - Canis familiaris [Reaction:R-RNO-9915968] 8,9-EET is hydrolysed to 8.9-DHET by EPHX2 - Rattus norvegicus [Reaction:R-MMU-9915968] 8,9-EET is hydrolysed to 8.9-DHET by EPHX2 - Mus musculus
output	[SimpleEntity:R-ALL-2142765] 8,9-DHET [cytosol]
precedingEvent	[Reaction:R-HSA-2161899] Arachidonate is epoxidated to 8,9-EET by CYP(5) - Homo sapiens
releaseDate	2024-09-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9917333] Hill, David P, 2024-08-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9915968
summation	[Summation:9915987] Epoxide hydrolase 2 (EPHX2) hydrolyses 8,9-epoxyeicosatrieno...

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[Pathway:R-HSA-2142670] Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)

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