Reactome | Arachidonate is epoxidated to 8,9-EET by CYP(5)

Arachidonate is epoxidated to 8,9-EET by CYP(5)

Stable Identifier

R-HSA-2161899

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

Synonyms

5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced (NADPH--hemoprotein reductase) => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized (NADPH--hemoprotein reductase)

ReviewStatus

5/5

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Arachidonate is epoxidated to 8,9-EET by CYP(5)

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Several cytochrome P450s (CYPs) convert arachidonate to 8,9-epoxyeicosatrienoate (8,9-EET). The CYPs and their references are: CYP1A1, CYP1A2, CYP1B1 (Choudhary et al. 2004); CYP2C8, CYP2C9 (Rifkind et al. 1995); CYP2C19 (Bylund et al. 1998, Rifkind et al. 1995); CYP2J2 (Wu et al. 1996).

Literature References

PubMed ID	Title	Journal	Year
9866708	Analysis of cytochrome P450 metabolites of arachidonic and linoleic acids by liquid chromatography-mass spectrometry with ion trap MS Ericsson, J, Oliw, EH, Bylund, J	Anal Biochem	1998
7625847	Arachidonic acid metabolism by human cytochrome P450s 2C8, 2C9, 2E1, and 1A2: regioselective oxygenation and evidence for a role for CYP2C enzymes in arachidonic acid epoxygenation in human liver microsomes Waxman, DJ, Chang, TK, Lee, C, Rifkind, AB	Arch Biochem Biophys	1995
8631948	Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart Falck, JR, Wu, S, Zeldin, DC, Moomaw, CR, Tomer, KB	J Biol Chem	1996
15258110	Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1 Stoilov, I, Choudhary, D, Schenkman, JB, Sarfarazi, M, Jansson, I	Drug Metab Dispos	2004