Arachidonate is epoxidated to 8,9-EET by CYP(5)

Stable Identifier
R-HSA-2161899
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced (NADPH--hemoprotein reductase) => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized (NADPH--hemoprotein reductase)
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Several cytochrome P450s (CYPs) convert arachidonate to 8,9-epoxyeicosatrienoate (8,9-EET). The CYPs and their references are: CYP1A1, CYP1A2, CYP1B1 (Choudhary et al. 2004); CYP2C8, CYP2C9 (Rifkind et al. 1995); CYP2C19 (Bylund et al. 1998, Rifkind et al. 1995); CYP2J2 (Wu et al. 1996).
Participants
Participates
Catalyst Activity

monooxygenase activity of CYP(5) [endoplasmic reticulum membrane]

Orthologous Events
Cross References
RHEA
Authored
Reviewed
Created
Cite Us!