Reactome | NOTCH1 Intracellular Domain Regulates Transcription

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NOTCH1 Intracellular Domain Regulates Transcription Show undefined attributes

authored	[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2122949] Orlic-Milacic, M, 2012-02-14
dbId	2122947
displayName	NOTCH1 Intracellular Domain Regulates Transcription
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2098673] D'Eustachio, P, 2012-02-06
eventOf	[Pathway:R-HSA-1980143] Signaling by NOTCH1 - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-1912388] NICD1 displaces co-repressor complex from RBPJ (CSL) - Homo sapiens [Reaction:R-HSA-1912394] NICD1 in complex with RBPJ (CSL) recruits MAML - Homo sapiens [Reaction:R-HSA-4396347] NOTCH1 Coactivator Complex binds HES1 promoter - Homo sapiens [BlackBoxEvent:R-HSA-1980047] NOTCH1 stimulates HES1 transcription - Homo sapiens [Reaction:R-HSA-1912359] HES1 binds TLE - Homo sapiens [Reaction:R-HSA-4396371] NOTCH1 Coactivator Complex binds MYC promoter - Homo sapiens [BlackBoxEvent:R-HSA-1980067] NOTCH1 stimulates MYC transcription - Homo sapiens [Reaction:R-HSA-4396379] NOTCH1 Coactivator Complex binds HES5 promoter - Homo sapiens [BlackBoxEvent:R-HSA-1980078] NOTCH1 stimulates HES5 transcription - Homo sapiens [Reaction:R-HSA-4396382] NOTCH1 Coactivator Complex binds promoters of HEY genes - Homo sapiens [BlackBoxEvent:R-HSA-1980065] NOTCH1 stimulates HEY transcription - Homo sapiens [Reaction:R-HSA-1912393] MAML in complex with NICD1 recruits CDK8 - Homo sapiens [Reaction:R-HSA-1912391] NICD1 is phosphorylated by CDK8 - Homo sapiens [Reaction:R-HSA-1912385] Phosphorylated NICD1 binds FBXW7 - Homo sapiens [Reaction:R-HSA-1852623] Ubiquitination of NICD1 by FBWX7 - Homo sapiens [Reaction:R-HSA-1912396] NICD1 binds HIF1A - Homo sapiens [BlackBoxEvent:R-HSA-9667638] NBEA translocates to the nucleus - Homo sapiens [Reaction:R-HSA-9667657] NBEA binds NICD1 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2020-03-16
literatureReference	[LiteratureReference:2063949] A histone deacetylase corepressor complex regulates the Notch signal transduction pathway [LiteratureReference:351549] SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function [LiteratureReference:383069] A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors [LiteratureReference:2063951] TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints [LiteratureReference:351538] Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex [LiteratureReference:2064894] p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro [LiteratureReference:208099] Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes [LiteratureReference:1602204] Signalling downstream of activated mammalian Notch [LiteratureReference:1911382] Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes [LiteratureReference:1911389] The Notch target genes Hey1 and Hey2 are required for embryonic vascular development [LiteratureReference:1890288] Analysis of HeyL expression in wild-type and Notch pathway mutant mouse embryos [LiteratureReference:2065301] Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes [LiteratureReference:1602205] NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth [LiteratureReference:2065503] Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif [LiteratureReference:2065501] The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain [LiteratureReference:2065514] Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins [LiteratureReference:351516] Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover [LiteratureReference:2064850] The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog [LiteratureReference:2064869] SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation [LiteratureReference:2064874] FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation [LiteratureReference:1604416] Hypoxia requires notch signaling to maintain the undifferentiated cell state [LiteratureReference:2252642] Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells
maxDepth	2
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	NOTCH1 Intracellular Domain Regulates Transcription
orthologousEvent	[Pathway:R-MMU-2122947] NOTCH1 Intracellular Domain Regulates Transcription - Mus musculus [Pathway:R-GGA-2122947] NOTCH1 Intracellular Domain Regulates Transcription - Gallus gallus
previousReviewStatus	[ReviewStatus:9821382] five stars
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2121207] Haw, R, 2012-02-06
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2122947
summation	[Summation:2122958] NICD1 produced by activation of NOTCH1 in response to Delta ...
updateTrackers	[UpdateTracker:9777363] Update Tracker - [Pathway:2122947] NOTCH1 Intracellular Domain Regulates Transcription - v72:[addHasEvent] [UpdateTracker:9788523] Update Tracker - [Pathway:2122947] NOTCH1 Intracellular Domain Regulates Transcription - v41:[addLiteratureReference, modifyText, updateContainedRLE] [UpdateTracker:9787788] Update Tracker - [Pathway:2122947] NOTCH1 Intracellular Domain Regulates Transcription - v44:[updateContainedRLE] [UpdateTracker:9787106] Update Tracker - [Pathway:2122947] NOTCH1 Intracellular Domain Regulates Transcription - v46:[addHasEvent, updateContainedRLE]

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[Pathway:R-HSA-1980143] Signaling by NOTCH1

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