Reactome | HES1 binds TLE

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HES1 binds TLE Show undefined attributes

authored	[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:1912360] Orlic-Milacic, M, 2011-11-01
dbId	1912359
displayName	HES1 binds TLE
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2098673] D'Eustachio, P, 2012-02-06
eventOf	[Pathway:R-HSA-2122947] NOTCH1 Intracellular Domain Regulates Transcription - Homo sapiens
inferredFrom	[Reaction:R-NUL-2065510] rHes1 binds TLE - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-210825] HES1 [nucleoplasm] [DefinedSet:R-HSA-212370] TLE [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:2065503] Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif [LiteratureReference:2065501] The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain [LiteratureReference:2065514] Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	HES1 binds TLE
output	[Complex:R-HSA-1911448] HES1:TLE [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-1980047] NOTCH1 stimulates HES1 transcription - Homo sapiens
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2121207] Haw, R, 2012-02-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1912359
summation	[Summation:2065517] Enhancer of split, a Drosophila orthologue of HES, is a basi...

Referrals

(hasEvent)	[Pathway:R-HSA-2122947] NOTCH1 Intracellular Domain Regulates Transcription
(inferredTo)	[Reaction:R-NUL-2065510] rHes1 binds TLE