Reactome | NOTCH1 Coactivator Complex binds HES1 promoter

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NOTCH1 Coactivator Complex binds HES1 promoter Show undefined attributes

authored	[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:4396359] Orlic-Milacic, M, 2013-08-22
dbId	4396347
diseaseReaction	[Reaction:R-HSA-4396392] NOTCH1 PEST domain mutants bind HES1 promoter - Homo sapiens
displayName	NOTCH1 Coactivator Complex binds HES1 promoter
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2098673] D'Eustachio, P, 2012-02-06 [InstanceEdit:8959863] Orlic-Milacic, Marija, 2017-01-31
eventOf	[Pathway:R-HSA-2122947] NOTCH1 Intracellular Domain Regulates Transcription - Homo sapiens [Pathway:R-HSA-8941856] RUNX3 regulates NOTCH signaling - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-1980047] NOTCH1 stimulates HES1 transcription - Homo sapiens
inferredFrom	[Reaction:R-NUL-4396363] mNICD1 Chimeric Enhancer Complex binds Hes1 promoter - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-2197548] HES1 gene [nucleoplasm] [Complex:R-HSA-1604462] NOTCH1 Coactivator Complex [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:1602204] Signalling downstream of activated mammalian Notch
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NOTCH1 Coactivator Complex binds HES1 promoter
output	[Complex:R-HSA-4396364] NOTCH1 Coactivator Complex:HES1 Gene [nucleoplasm]
precedingEvent	[Reaction:R-HSA-1912394] NICD1 in complex with RBPJ (CSL) recruits MAML - Homo sapiens
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2121207] Haw, R, 2012-02-06 [InstanceEdit:8959885] Ito, Yoshiaki, 2017-01-31 [InstanceEdit:8959883] Chuang, Linda Shyue Huey, 2017-01-31
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4396347
summation	[Summation:4396356] NOTCH1 coactivator complex binds the promoter of HES1 gene a...

Referrals

(normalReaction)	[Reaction:R-HSA-4396392] NOTCH1 PEST domain mutants bind HES1 promoter
(hasEvent)	[Pathway:R-HSA-8941856] RUNX3 regulates NOTCH signaling [Pathway:R-HSA-2122947] NOTCH1 Intracellular Domain Regulates Transcription
(precedingEvent)	[BlackBoxEvent:R-HSA-1980047] NOTCH1 stimulates HES1 transcription
(inferredTo)	[Reaction:R-NUL-4396363] mNICD1 Chimeric Enhancer Complex binds Hes1 promoter

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