Reactome | Phosphorylated NICD1 binds FBXW7

Schema > Reaction > Entries

Phosphorylated NICD1 binds FBXW7 Show undefined attributes

authored	[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:1912384] Orlic-Milacic, M, 2011-11-01
dbId	1912385
diseaseReaction	[FailedReaction:R-HSA-2220978] FBXW7 WD mutants do not bind NICD1 - Homo sapiens [FailedReaction:R-HSA-2220967] p-NICD1 PEST domain mutants do not bind FBXW7 - Homo sapiens
displayName	Phosphorylated NICD1 binds FBXW7
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2098673] D'Eustachio, P, 2012-02-06
eventOf	[Pathway:R-HSA-2122947] NOTCH1 Intracellular Domain Regulates Transcription - Homo sapiens
followingEvent	[Reaction:R-HSA-1852623] Ubiquitination of NICD1 by FBWX7 - Homo sapiens
inferredFrom	[Reaction:R-NUL-2064853] FBXW7 binds phosphorylated NICD1 - Homo sapiens
input	[Complex:R-HSA-1604469] FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-1604444] p-NICD1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:2064850] The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog [LiteratureReference:351516] Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover [LiteratureReference:2064874] FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation [LiteratureReference:2064869] SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylated NICD1 binds FBXW7
output	[Complex:R-HSA-1604468] p-NICD1:FBXW7:SKP1:CUL1:RBX1 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-1912391] NICD1 is phosphorylated by CDK8 - Homo sapiens
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2121207] Haw, R, 2012-02-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1912385
summation	[Summation:2064868] The E3 ubiquitin ligase FBXW7, a homologue of C. elegans sel...
updateTrackers	[UpdateTracker:9787693] Update Tracker - [Reaction:1912385] Phosphorylated NICD1 binds FBXW7 - v44:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9787693] Update Tracker - [Reaction:1912385] Phosphorylated NICD1 binds FBXW7 - v44:[addLiteratureReference]
(normalReaction)	[FailedReaction:R-HSA-2220978] FBXW7 WD mutants do not bind NICD1 [FailedReaction:R-HSA-2220967] p-NICD1 PEST domain mutants do not bind FBXW7
(hasEvent)	[Pathway:R-HSA-2122947] NOTCH1 Intracellular Domain Regulates Transcription
(precedingEvent)	[Reaction:R-HSA-1852623] Ubiquitination of NICD1 by FBWX7
(inferredTo)	[Reaction:R-NUL-2064853] FBXW7 binds phosphorylated NICD1