Reactome | PRC2 recruits DNA methyltransferases

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PRC2 recruits DNA methyltransferases Show undefined attributes

authored	[InstanceEdit:212086] May, B, Gopinathrao, G, 2008-02-08 19:50:06
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:212319] May, B, Gopinathrao, G, 2008-02-08 20:37:25
dbId	212222
displayName	PRC2 recruits DNA methyltransferases
edited	[InstanceEdit:565730] May, B, 2010-04-06
eventOf	[Pathway:R-HSA-212300] PRC2 methylates histones and DNA - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-212269] DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 - Homo sapiens [BlackBoxEvent:R-HSA-9710490] The GSDME gene promoter is hypermethylated - Homo sapiens
input	[DefinedSet:R-HSA-212315] DNMT1,3A,3B [nucleoplasm] [Complex:R-HSA-5084071] PRC2 Core:Chromatin [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:212233] The Polycomb group protein EZH2 directly controls DNA methylation
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	PRC2 recruits DNA methyltransferases
orthologousEvent	[Reaction:R-GGA-212222] PRC2 recruits DNA methyltransferases - Gallus gallus [Reaction:R-XTR-212222] PRC2 recruits DNA methyltransferases - Xenopus tropicalis [Reaction:R-DRE-212222] PRC2 recruits DNA methyltransferases - Danio rerio [Reaction:R-SSC-212222] PRC2 recruits DNA methyltransferases - Sus scrofa [Reaction:R-BTA-212222] PRC2 recruits DNA methyltransferases - Bos taurus [Reaction:R-CFA-212222] PRC2 recruits DNA methyltransferases - Canis familiaris [Reaction:R-RNO-212222] PRC2 recruits DNA methyltransferases - Rattus norvegicus [Reaction:R-MMU-212222] PRC2 recruits DNA methyltransferases - Mus musculus
output	[Complex:R-HSA-212288] DNMT1,3A,3B:PRC2:Chromatin [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-212252] Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin - Homo sapiens
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5263607] Di Croce, Luciano, 2014-02-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-212222
summation	[Summation:212279] In tumor cells the Polycomb Repressor Complex 2 associates w...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-212269] DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 [BlackBoxEvent:R-HSA-9710490] The GSDME gene promoter is hypermethylated
(hasEvent)	[Pathway:R-HSA-212300] PRC2 methylates histones and DNA