Reactome | PRC2 recruits DNA methyltransferases

PRC2 recruits DNA methyltransferases

Stable Identifier

R-HSA-212222

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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In tumor cells the Polycomb Repressor Complex 2 associates with a DNA methyltransferase (DNMT) via the N-terminal region of EZH2 (Vire et al. 2006). DNMT1, DNMT3a, and DNMT3b can each bind EZH2 though only one is bound at any time. As inferred from mouse (Rush et al. 2009), EZH2 tethered to a locus is able to recruit Dnmt3a but additional factors may be required to trigger de novo DNA methylation. It is unknown if the DNMT is recruited only after PRC2 has been targeted to a locus.

Literature References

PubMed ID	Title	Journal	Year
16357870	The Polycomb group protein EZH2 directly controls DNA methylation Viré, E, Brenner, C, Deplus, R, Blanchon, L, Fraga, M, Didelot, C, Morey, L, Van Eynde, A, Bernard, D, Vanderwinden, JM, Bollen, M, Esteller, M, Di Croce, L, de Launoit, Y, Fuks, F	Nature	2006