PRC2 recruits DNA methyltransferases

Stable Identifier
R-HSA-212222
Type
Reaction [binding]
Species
Homo sapiens
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In tumor cells the Polycomb Repressor Complex 2 associates with a DNA methyltransferase (DNMT) via the N-terminal region of EZH2 (Vire et al. 2006). DNMT1, DNMT3a, and DNMT3b can each bind EZH2 though only one is bound at any time. As inferred from mouse (Rush et al. 2009), EZH2 tethered to a locus is able to recruit Dnmt3a but additional factors may be required to trigger de novo DNA methylation. It is unknown if the DNMT is recruited only after PRC2 has been targeted to a locus.

Literature References
PubMed ID Title Journal Year
16357870 The Polycomb group protein EZH2 directly controls DNA methylation

Viré, E, Brenner, C, Deplus, R, Blanchon, L, Fraga, M, Didelot, C, Morey, L, Van Eynde, A, Bernard, D, Vanderwinden, JM, Bollen, M, Esteller, M, Di Croce, L, de Launoit, Y, Fuks, F

Nature 2006
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