In tumor cells the Polycomb Repressor Complex 2 associates w...

created [InstanceEdit:212319] May, B, Gopinathrao, G, 2008-02-08 20:37:25
dbId 212279
displayName In tumor cells the Polycomb Repressor Complex 2 associates w...
literatureReference
modified [InstanceEdit:5263608] May, B, 2014-02-11
schemaClass Summation
text In tumor cells the Polycomb Repressor Complex 2 associates with a DNA methyltransferase (DNMT) via the N-terminal region of EZH2 (Vire et al. 2006). DNMT1, DNMT3a, and DNMT3b can each bind EZH2 though only one is bound at any time. As inferred from mouse (Rush et al. 2009), EZH2 tethered to a locus is able to recruit Dnmt3a but additional factors may be required to trigger de novo DNA methylation. It is unknown if the DNMT is recruited only after PRC2 has been targeted to a locus.
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