Reactome | DNMT1 [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

DNMT1 [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-5334177] DNMT1:UHRF1:symmetrically methylated DNA [nucleoplasm] - Homo sapiens [Complex:R-HSA-212159] DNMT1:UHRF1:hemimethylated DNA [nucleoplasm] - Homo sapiens [Complex:R-HSA-427410] NoRC:pRNA:HDAC:DNMT [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-4655431] SUMOyation of DNMT1 with SUMO1 - Homo sapiens [Reaction:R-HSA-9851071] STAT3, DNMT1 and HDAC1 bind PTPN6 gene - Homo sapiens [Reaction:R-HSA-9851058] AcK685 p-Y705, S727 STAT3 dimer and DNMT1 bind IL2RG gene - Homo sapiens [Reaction:R-HSA-5334160] UHRF1:Chromatin binds DNMT1 - Homo sapiens [Reaction:R-HSA-427409] Nucleolar Remodelling Complex (NoRC) binds intergenic region of rDNA - Homo sapiens
created	[InstanceEdit:212086] May, B, Gopinathrao, G, 2008-02-08 19:50:06
dbId	212181
displayName	DNMT1 [nucleoplasm]
endCoordinate	1616
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-212181] DNMT1 [nucleoplasm] - Mus musculus [EntityWithAccessionedSequence:R-RNO-212181] DNMT1 [nucleoplasm] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-212181] DNMT1 [nucleoplasm] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-212181] DNMT1 [nucleoplasm] - Bos taurus [EntityWithAccessionedSequence:R-SSC-212181] DNMT1 [nucleoplasm] - Sus scrofa [EntityWithAccessionedSequence:R-XTR-212181] dnmt1 [nucleoplasm] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-212181] DNMT1 [nucleoplasm] - Gallus gallus
maxDepth	1
memberOf	[DefinedSet:R-HSA-212315] DNMT1,3A,3B [nucleoplasm] - Homo sapiens
modified	[InstanceEdit:3132750] Wu, G, 2013-02-13
name	DNMT1
negativelyRegulates	[NegativeGeneExpressionRegulation:9850965] Negative gene expression regulation by 'DNMT1 [nucleoplasm]'
producedByEvent	[BlackBoxEvent:R-HSA-9851145] Translation of DNMT1 mRNA is repressed by miR-21 - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:P26358] UniProt:P26358 DNMT1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-212181
startCoordinate	1

Referrals

(input)	[Reaction:R-HSA-4655431] SUMOyation of DNMT1 with SUMO1 [Reaction:R-HSA-427409] Nucleolar Remodelling Complex (NoRC) binds intergenic region of rDNA [Reaction:R-HSA-5334160] UHRF1:Chromatin binds DNMT1 [Reaction:R-HSA-9851071] STAT3, DNMT1 and HDAC1 bind PTPN6 gene [Reaction:R-HSA-9851058] AcK685 p-Y705, S727 STAT3 dimer and DNMT1 bind IL2RG gene
(hasComponent)	[Complex:R-HSA-427410] NoRC:pRNA:HDAC:DNMT [nucleoplasm] [Complex:R-HSA-5334177] DNMT1:UHRF1:symmetrically methylated DNA [nucleoplasm] [Complex:R-HSA-212159] DNMT1:UHRF1:hemimethylated DNA [nucleoplasm] [Complex:R-HSA-9850942] pY705, S727 STAT dimer:DNMT1:HDAC1:PTPN6 gene [nucleoplasm] [Complex:R-HSA-9850883] DNMT1:AcK685-p-Y705, S727 STAT3 dimer:IL2RG gene [nucleoplasm]
(activeUnit)	[CatalystActivity:5334139] DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates of DNMT1:UHRF1:Chromatin with hemimethylC [nucleoplasm] [NegativeGeneExpressionRegulation:9850965] Negative gene expression regulation by 'DNMT1 [nucleoplasm]' [NegativeGeneExpressionRegulation:9850971] Negative gene expression regulation by 'pY705, S727 STAT dimer:DNMT1:HDAC1:PTPN6 gene [nucleoplasm]' [NegativeGeneExpressionRegulation:9850955] Negative gene expression regulation by 'DNMT1:AcK685-p-Y705, S727 STAT3 dimer:IL2RG gene [nucleoplasm]'
(hasMember)	[DefinedSet:R-HSA-212315] DNMT1,3A,3B [nucleoplasm]
(regulator)	[NegativeGeneExpressionRegulation:9850965] Negative gene expression regulation by 'DNMT1 [nucleoplasm]'
(output)	[BlackBoxEvent:R-HSA-9851145] Translation of DNMT1 mRNA is repressed by miR-21
(requiredInputComponent)	[Reaction:R-HSA-9817458] TET3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine in chromatin containing histone H3.3

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