Sterols are 12-hydroxylated by CYP8B1

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R-HSA-211994
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Homo sapiens
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Cytochrome P450 8B1 (CYP8B1, sterol 12-alpha- hydroxylase) has a broad substrate specificity including a number of 7-alpha- hydroxylated C27 steroids. It is also involved in bile acid synthesis and is responsible for the balance between the formation of cholic acid and chenodeoxycholic acid (Gafvels et al. 1999).

Literature References
PubMed ID Title Journal Year
10051404 Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns

Gafvels, M, Olin, M, Chowdhary, BP, Raudsepp, T, Andersson, U, Persson, B, Jansson, M, Bjorkhem, I, Eggertsen, G

Genomics 1999
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