Reactome | Sterols are 12-hydroxylated by CYP8B1

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Sterols are 12-hydroxylated by CYP8B1 Show undefined attributes

compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10729422
displayName	Sterols are 12-hydroxylated by CYP8B1
eventOf	[Pathway:R-XTR-211976] Endogenous sterols - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:13620] sterol metabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-XTR-193709] CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL - Xenopus tropicalis [Reaction:R-XTR-193845] CYP8B1 12-hydroxylates 4CHOL7a,27DONE - Xenopus tropicalis [Reaction:R-XTR-192157] CYP8B1 12-hydroxylates 4CHOL7aOLONE - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-211994] Sterols are 12-hydroxylated by CYP8B1 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Sterols are 12-hydroxylated by CYP8B1
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-211994
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-211976] Endogenous sterols
(inferredTo)	[Pathway:R-HSA-211994] Sterols are 12-hydroxylated by CYP8B1

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