Reactome | Duplex miRNA is loaded into Argonaute

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Duplex miRNA is loaded into Argonaute Show undefined attributes

authored	[InstanceEdit:2089962] May, B, 2012-02-05
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2106631] May, B, 2012-02-10
dbId	2106614
displayName	Duplex miRNA is loaded into Argonaute
edited	[InstanceEdit:2089962] May, B, 2012-02-05
eventOf	[Pathway:R-HSA-203927] MicroRNA (miRNA) biogenesis - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-210805] Removal of miRNA passenger strand - Homo sapiens
input	[DefinedSet:R-HSA-6789248] TARBP2,PRKRA RLC:duplex miRNA [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:426461] A human, ATP-independent, RISC assembly machine fueled by pre-miRNA [LiteratureReference:426470] In vitro reconstitution of the human RISC-loading complex [LiteratureReference:203825] TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing [LiteratureReference:203854] TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing [LiteratureReference:2106617] Dicer is dispensable for asymmetric RISC loading in mammals [LiteratureReference:1296406] ATP-dependent human RISC assembly pathways [LiteratureReference:6789239] Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing [LiteratureReference:6789258] The rough endoplasmatic reticulum is a central nucleation site of siRNA-mediated RNA silencing [LiteratureReference:6789287] siRNA repositioning for guide strand selection by human Dicer complexes [LiteratureReference:6789394] DICER-ARGONAUTE2 complex in continuous fluorogenic assays of RNA interference enzymes [LiteratureReference:6789425] microRNAs associated with the different human Argonaute proteins
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Duplex miRNA is loaded into Argonaute
orthologousEvent	[BlackBoxEvent:R-SSC-2106614] Duplex miRNA is loaded into Argonaute - Sus scrofa [BlackBoxEvent:R-CEL-2106614] Duplex miRNA is loaded into Argonaute - Caenorhabditis elegans [BlackBoxEvent:R-DME-2106614] Duplex miRNA is loaded into Argonaute - Drosophila melanogaster [BlackBoxEvent:R-GGA-2106614] Duplex miRNA is loaded into Argonaute - Gallus gallus [BlackBoxEvent:R-XTR-2106614] Duplex miRNA is loaded into Argonaute - Xenopus tropicalis [BlackBoxEvent:R-BTA-2106614] Duplex miRNA is loaded into Argonaute - Bos taurus [BlackBoxEvent:R-CFA-2106614] Duplex miRNA is loaded into Argonaute - Canis familiaris [BlackBoxEvent:R-RNO-2106614] Duplex miRNA is loaded into Argonaute - Rattus norvegicus [BlackBoxEvent:R-MMU-2106614] Duplex miRNA is loaded into Argonaute - Mus musculus
output	[DefinedSet:R-HSA-6789253] TARBP2,PRKRA:DICER1:Pre-RISC (miRNA) [cytosol]
precedingEvent	[Reaction:R-HSA-203862] Dicer cleaves pre-miRNA to yield duplex miRNA - Homo sapiens
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2106616] Tomari, Y, 2012-02-10
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-2106614
summation	[Summation:2106610] The duplex miRNA (designated miRNA-miRNA*) is reoriented on ...
updateTrackers	[UpdateTracker:9784422] Update Tracker - [BlackBoxEvent:2106614] Duplex miRNA is loaded into Argonaute - v54:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText] [UpdateTracker:9788494] Update Tracker - [BlackBoxEvent:2106614] Duplex miRNA is loaded into Argonaute - v42:[addOutput] [UpdateTracker:9787261] Update Tracker - [BlackBoxEvent:2106614] Duplex miRNA is loaded into Argonaute - v46:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9784422] Update Tracker - [BlackBoxEvent:2106614] Duplex miRNA is loaded into Argonaute - v54:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText] [UpdateTracker:9788494] Update Tracker - [BlackBoxEvent:2106614] Duplex miRNA is loaded into Argonaute - v42:[addOutput] [UpdateTracker:9787261] Update Tracker - [BlackBoxEvent:2106614] Duplex miRNA is loaded into Argonaute - v46:[modifyText]
(hasEvent)	[Pathway:R-HSA-203927] MicroRNA (miRNA) biogenesis
(precedingEvent)	[BlackBoxEvent:R-HSA-210805] Removal of miRNA passenger strand

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