Reactome | MicroRNA (miRNA) biogenesis

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MicroRNA (miRNA) biogenesis Show undefined attributes

authored	[InstanceEdit:203918] Gopinathrao, G, May, B, 2007-11-18 23:55:40
compartment	[Compartment:7660] nucleoplasm [Compartment:13231] nuclear envelope [Compartment:70101] cytosol
created	[InstanceEdit:203816] Gopinathrao, G, 2007-11-18 23:55:40
dbId	203927
displayName	MicroRNA (miRNA) biogenesis
doi	10.3180/REACT_12417.1
edited	[InstanceEdit:398129] May, B, 2009-03-17 16:05:37
eventOf	[Pathway:R-HSA-211000] Gene Silencing by RNA - Homo sapiens
figure	[Figure:209684] /figures/miRNA_toplevel.jpg
goBiologicalProcess	[GO_BiologicalProcess:357860] miRNA metabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-HSA-203901] Pol II mediated transcription of microRNA genes - Homo sapiens [Reaction:R-HSA-203893] Microprocessor complex cleaves pri-miRNA to pre-miRNA - Homo sapiens [Reaction:R-HSA-203922] Exportin-5 recognizes 3' overhang of pre-miRNA - Homo sapiens [Reaction:R-HSA-203906] Exportin complex translocates pre-miRNA to cytosol - Homo sapiens [Reaction:R-HSA-203862] Dicer cleaves pre-miRNA to yield duplex miRNA - Homo sapiens [BlackBoxEvent:R-HSA-2106614] Duplex miRNA is loaded into Argonaute - Homo sapiens [BlackBoxEvent:R-HSA-210805] Removal of miRNA passenger strand - Homo sapiens [Reaction:R-HSA-5578717] BCDIN3D dimethylates 5' phosphate of pre-miR-145 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2017-12-18
literatureReference	[LiteratureReference:210562] MicroRNAs: small RNAs with a big role in gene regulation [LiteratureReference:210581] The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 [LiteratureReference:210591] A microRNA polycistron as a potential human oncogene [LiteratureReference:203811] Identification of mammalian microRNA host genes and transcription units [LiteratureReference:1499922] microRNA Biogenesis and Function : An overview [LiteratureReference:1499920] MicroRNAs: biogenesis, function and applications [LiteratureReference:1499924] Intronic microRNA (miRNA) [LiteratureReference:2089964] Biogenesis of small RNAs in animals [LiteratureReference:6789258] The rough endoplasmatic reticulum is a central nucleation site of siRNA-mediated RNA silencing [LiteratureReference:5579131] RNAi factors are present and active in human cell nuclei
maxDepth	2
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	MicroRNA (miRNA) biogenesis
orthologousEvent	[Pathway:R-MMU-203927] MicroRNA (miRNA) biogenesis - Mus musculus [Pathway:R-RNO-203927] MicroRNA (miRNA) biogenesis - Rattus norvegicus [Pathway:R-CFA-203927] MicroRNA (miRNA) biogenesis - Canis familiaris [Pathway:R-BTA-203927] MicroRNA (miRNA) biogenesis - Bos taurus [Pathway:R-XTR-203927] MicroRNA (miRNA) biogenesis - Xenopus tropicalis [Pathway:R-GGA-203927] MicroRNA (miRNA) biogenesis - Gallus gallus [Pathway:R-DME-203927] MicroRNA (miRNA) biogenesis - Drosophila melanogaster [Pathway:R-CEL-203927] MicroRNA (miRNA) biogenesis - Caenorhabditis elegans [Pathway:R-SSC-203927] MicroRNA (miRNA) biogenesis - Sus scrofa
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:212012] Karginov, F, Hannon, GJ, 2008-02-08 15:41:16
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-203927
summation	[Summation:209658] Biogenesis of microRNAs (miRNAs) can be summarized in five s...
updateTrackers	[UpdateTracker:9780328] Update Tracker - [Pathway:203927] MicroRNA (miRNA) biogenesis - v63:[addHasEvent] [UpdateTracker:9784514] Update Tracker - [Pathway:203927] MicroRNA (miRNA) biogenesis - v54:[addLiteratureReference, modifyText, updateContainedRLE] [UpdateTracker:9788813] Update Tracker - [Pathway:203927] MicroRNA (miRNA) biogenesis - v40:[addHasEvent, addLiteratureReference, modifyText, updateContainedRLE] [UpdateTracker:9781689] Update Tracker - [Pathway:203927] MicroRNA (miRNA) biogenesis - v60:[updateContainedRLE] [UpdateTracker:9787318] Update Tracker - [Pathway:203927] MicroRNA (miRNA) biogenesis - v45:[updateContainedRLE] [UpdateTracker:9791423] Update Tracker - [Pathway:203927] MicroRNA (miRNA) biogenesis - v30:[modifyText, updateContainedRLE] [UpdateTracker:9788424] Update Tracker - [Pathway:203927] MicroRNA (miRNA) biogenesis - v42:[updateContainedRLE] [UpdateTracker:9789111] Update Tracker - [Pathway:203927] MicroRNA (miRNA) biogenesis - v38:[addLiteratureReference, modifyText, updateContainedRLE] [UpdateTracker:9787124] Update Tracker - [Pathway:203927] MicroRNA (miRNA) biogenesis - v46:[modifyText, updateContainedRLE] [UpdateTracker:9786021] Update Tracker - [Pathway:203927] MicroRNA (miRNA) biogenesis - v50:[updateContainedRLE] [UpdateTracker:9790554] Update Tracker - [Pathway:203927] MicroRNA (miRNA) biogenesis - v33:[updateContainedRLE]

Referrals

(hasEvent)

[Pathway:R-HSA-211000] Gene Silencing by RNA

(updatedInstance)

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