Reactome | Negative gene expression regulation by 'p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm]'

Schema > NegativeGeneExpressionRegulation > Entries

created	[InstanceEdit:2186614] Orlic-Milacic, M, 2012-04-04
dbId	2186613
displayName	Negative gene expression regulation by 'p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm]'
modified	[InstanceEdit:9608020] Wu, G, 2018-05-08
regulatedEntity	[BlackBoxEvent:R-HSA-2106586] WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it - Homo sapiens
regulator	[Complex:R-HSA-2186606] p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm]
schemaClass	NegativeGeneExpressionRegulation
stId	R-HSA-2186613

(regulation)	[RegulationReference:9642819] Negative gene expression regulation by 'p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm]' TGIF2 interacts with histone deacetylase 1 and represses transcription
(regulatedBy)	[BlackBoxEvent:R-HSA-2106586] WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it

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