Reactome | FGFR3 mutant dimers [plasma membrane]

Schema > DefinedSet > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-2077417] FGFR3 mutant dimers:TKIs [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-2077420] FGFR3 mutants bind and are inactivated by tyrosine kinase inhibitors - Homo sapiens
created	[InstanceEdit:2077413] Rothfels, K, 2012-01-27
crossReference	[DatabaseIdentifier:12020828] Mondo:0005497
dbId	2077412
disease	[Disease:2032940] bone development disease [Disease:1500689] cancer
displayName	FGFR3 mutant dimers [plasma membrane]
hasMember	[Complex:R-HSA-2011952] FGFR3c P250R mutant dimer bound to FGF [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-2038375] FGFR3 (4;14) translocation mutant dimers [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-2033383] FGFR3 point mutant dimers with enhanced kinase activity [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-2012041] FGFR3 cysteine mutant dimers [plasma membrane] - Homo sapiens
inDisease	true
maxDepth	4
name	FGFR3 mutant dimers
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-2077412
updateTrackers	[UpdateTracker:9893830] Update Tracker - [DefinedSet:2077412] FGFR3 mutant dimers [plasma membrane] - v56:[updateContainedMemberOrCandidate]

(updatedInstance)	[UpdateTracker:9893830] Update Tracker - [DefinedSet:2077412] FGFR3 mutant dimers [plasma membrane] - v56:[updateContainedMemberOrCandidate]
(hasComponent)	[Complex:R-HSA-2077417] FGFR3 mutant dimers:TKIs [plasma membrane]
(input)	[Reaction:R-HSA-2077420] FGFR3 mutants bind and are inactivated by tyrosine kinase inhibitors
(diseaseEntity)	[EntityFunctionalStatus:5654521] gain_of_function of FGFR3 mutant dimers [plasma membrane]