Reactome | FGFR3c P250R mutant dimer bound to FGF [plasma membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:2012066] protein tyrosine kinase activity of FGFR3c P250R mutant dimer bound to FGF [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-HSA-2012073] Autocatalytic phosphorylation of FGFR3c P250R mutant - Homo sapiens
created	[InstanceEdit:2011953] Rothfels, K, 2011-11-22
crossReference	[DatabaseIdentifier:12020828] Mondo:0005497
dbId	2011952
disease	[Disease:2032940] bone development disease
displayName	FGFR3c P250R mutant dimer bound to FGF [plasma membrane]
hasComponent	[Complex:R-HSA-2011951] FGFR3c P250R mutant dimer [plasma membrane] 2 × [DefinedSet:R-HSA-189955] FGFR3c-binding FGFs [extracellular region] [SimpleEntity:R-ALL-190915] HS [extracellular region]
inDisease	true
includedLocation	[Compartment:984] extracellular region
isChimeric	false
maxDepth	3
memberOf	[DefinedSet:R-HSA-2077412] FGFR3 mutant dimers [plasma membrane] - Homo sapiens
modified	[InstanceEdit:2213009] Matthews, L, 2012-04-27
name	FGFR3c P250R mutant dimer bound to FGF
producedByEvent	[Reaction:R-HSA-2012074] FGFR3c P250R mutant binds to ligand with enhanced affinity - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-2011952
updateTrackers	[UpdateTracker:9893753] Update Tracker - [Complex:2011952] FGFR3c P250R mutant dimer bound to FGF [plasma membrane] - v56:[updateContainedComponent]

(updatedInstance)	[UpdateTracker:9893753] Update Tracker - [Complex:2011952] FGFR3c P250R mutant dimer bound to FGF [plasma membrane] - v56:[updateContainedComponent]
(input)	[Reaction:R-HSA-2012073] Autocatalytic phosphorylation of FGFR3c P250R mutant
(diseaseEntity)	[EntityFunctionalStatus:5654464] gain_of_function of FGFR3c P250R mutant dimer bound to FGF [plasma membrane]
(physicalEntity)	[CatalystActivity:2012066] protein tyrosine kinase activity of FGFR3c P250R mutant dimer bound to FGF [plasma membrane]
(output)	[Reaction:R-HSA-2012074] FGFR3c P250R mutant binds to ligand with enhanced affinity
(hasMember)	[DefinedSet:R-HSA-2077412] FGFR3 mutant dimers [plasma membrane]

Cite Us!