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Schema
>
Reaction
>
Entries
Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10))
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authored
[InstanceEdit:1998760] May, B, 2011-11-19
catalystActivity
[CatalystActivity:2065406] aspartic-type endopeptidase activity of Prorenin-Prorenin Receptor [plasma membrane]
catalystActivityReference
[CatalystActivityReference:9643694] aspartic-type endopeptidase activity of Prorenin-Prorenin Receptor [plasma membrane] Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin
category
transition
compartment
[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created
[InstanceEdit:2065361] May, B, 2012-01-21
dbId
2065357
displayName
Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10))
edited
[InstanceEdit:1998760] May, B, 2011-11-19
eventOf
[Pathway:R-HSA-2022377] Metabolism of Angiotensinogen to Angiotensins - Homo sapiens
followingEvent
[Reaction:R-HSA-2028294] Mast Cell Carboxypeptidase hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-33) (Angiotensin-(1-9)) - Homo sapiens
[Reaction:R-HSA-2022396] MME:Zn2+ (Neprilysin) hydrolyses AGT(25-34) (Angiotensin-(1-10)) to AGT(25-31) (Angiotensin-(1-7)) - Homo sapiens
[Reaction:R-HSA-2022411] Cathepsin G hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Homo sapiens
[Reaction:R-HSA-2022381] Cathepsin Z (Cathepsin X) hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Homo sapiens
[Reaction:R-HSA-2022383] Chymase hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Homo sapiens
[Reaction:R-HSA-2022378] ACE2(18-805):Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-33) (Angiotensin-(1-9)) - Homo sapiens
[Reaction:R-HSA-2022405] ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Homo sapiens
[Reaction:R-HSA-2065355] Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:172124] angiotensin maturation
input
[EntityWithAccessionedSequence:R-HSA-1998759] AGT [extracellular region]
[SimpleEntity:R-ALL-109276] H2O [extracellular region]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:2022186] Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin
[LiteratureReference:2065392] Aliskiren displays long-lasting interactions with human renin
[LiteratureReference:2065380] Structure-based design of aliskiren, a novel orally effective renin inhibitor
maxDepth
1
modified
[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name
Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10))
Prorenin Bound to Renin Receptor Hydrolyzes Angiotensinogen to Yield Angiotensin I
orthologousEvent
[Reaction:R-DME-2065357] Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10)) - Drosophila melanogaster
[Reaction:R-GGA-2065357] Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10)) - Gallus gallus
[Reaction:R-XTR-2065357] Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10)) - Xenopus tropicalis
[Reaction:R-DRE-2065357] Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10)) - Danio rerio
[Reaction:R-SSC-2065357] Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10)) - Sus scrofa
[Reaction:R-BTA-2065357] Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10)) - Bos taurus
[Reaction:R-CFA-2065357] Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10)) - Canis familiaris
[Reaction:R-RNO-2065357] Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10)) - Rattus norvegicus
[Reaction:R-MMU-2065357] Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10)) - Mus musculus
output
[EntityWithAccessionedSequence:R-HSA-2022346] AGT(25-34) [extracellular region]
precedingEvent
[BlackBoxEvent:R-HSA-1989774] Expression of AGT - Homo sapiens
regulatedBy
[NegativeRegulation:R-HSA-2065428] Negative regulation by 'aliskiren [extracellular region]'
regulationReference
[RegulationReference:9642602] Negative regulation by 'aliskiren [extracellular region]' Aliskiren displays long-lasting interactions with human renin
releaseDate
2012-09-18
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2426575] Joseph, J, 2012-08-06
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-2065357
summation
[Summation:2065370] The binding of prorenin to the (pro)renin receptor activates...
Referrals
(precedingEvent)
[Reaction:R-HSA-2028294] Mast Cell Carboxypeptidase hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-33) (Angiotensin-(1-9))
[Reaction:R-HSA-2022396] MME:Zn2+ (Neprilysin) hydrolyses AGT(25-34) (Angiotensin-(1-10)) to AGT(25-31) (Angiotensin-(1-7))
[Reaction:R-HSA-2022411] Cathepsin G hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))
[Reaction:R-HSA-2022381] Cathepsin Z (Cathepsin X) hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))
[Reaction:R-HSA-2022383] Chymase hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))
[Reaction:R-HSA-2022378] ACE2(18-805):Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-33) (Angiotensin-(1-9))
[Reaction:R-HSA-2022405] ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))
[Reaction:R-HSA-2065355] Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))
(hasEvent)
[Pathway:R-HSA-2022377] Metabolism of Angiotensinogen to Angiotensins
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