Reactome | Cathepsin G hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))

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Cathepsin G hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) Show undefined attributes

authored	[InstanceEdit:1998760] May, B, 2011-11-19
catalystActivity	[CatalystActivity:381447] serine-type endopeptidase activity of Cathepsin G [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643446] serine-type endopeptidase activity of Cathepsin G [plasma membrane] Inflammation-related neutrophil proteases, cathepsin G and elastase, function as insulin-like growth factor binding protein proteases
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:2022406] May, B, 2011-11-29
dbId	2022411
displayName	Cathepsin G hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))
edited	[InstanceEdit:1998760] May, B, 2011-11-19
eventOf	[Pathway:R-HSA-2022377] Metabolism of Angiotensinogen to Angiotensins - Homo sapiens
followingEvent	[Reaction:R-HSA-2022399] ENPEP:Zn2+ hydrolyzes AGT(25-32) (Angiotensin-(1-8)) to AGT(26-32) (Angiotensin-(2-8)) - Homo sapiens [BlackBoxEvent:R-HSA-9944540] AGT(25-32) is decarboxylated to yield 1-Ala-AGT(25-32) (des(Asp1)-(Ala1)-Ang II, Angiotensin A) - Homo sapiens [Reaction:R-HSA-2022379] ACE2(18-805):Zn2+ hydrolyzes AGT(25-32) (Angiotensin-(1-8)) to AGT(25-31) (Angiotensin-(1-7)) - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:172124] angiotensin maturation
input	[EntityWithAccessionedSequence:R-HSA-2022346] AGT(25-34) [extracellular region] [SimpleEntity:R-ALL-109276] H2O [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2022224] How immune peptidases change specificity: cathepsin G gained tryptic function but lost efficiency during primate evolution [LiteratureReference:2022268] Rapid conversion of angiotensin I to angiotensin II by neutrophil and mast cell proteinases [LiteratureReference:2022317] Angiotensin II generation at the cell surface of activated neutrophils: novel cathepsin G-mediated catalytic activity that is resistant to inhibition
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	Cathepsin G hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) Cathepsin G Hydrolyzes Angiotensin I to Yield Angiotensin II
orthologousEvent	[Reaction:R-XTR-2022411] Cathepsin G hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Xenopus tropicalis [Reaction:R-DRE-2022411] Cathepsin G hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Danio rerio [Reaction:R-SSC-2022411] Cathepsin G hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Sus scrofa [Reaction:R-BTA-2022411] Cathepsin G hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Bos taurus [Reaction:R-CFA-2022411] Cathepsin G hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Canis familiaris [Reaction:R-RNO-2022411] Cathepsin G hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Rattus norvegicus [Reaction:R-MMU-2022411] Cathepsin G hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-374187] AGT(25-32) [extracellular region]
precedingEvent	[Reaction:R-HSA-2022403] Renin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) - Homo sapiens [Reaction:R-HSA-2022412] Renin hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) - Homo sapiens [Reaction:R-HSA-2065357] Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10)) - Homo sapiens
releaseDate	2012-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2426575] Joseph, J, 2012-08-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2022411
summation	[Summation:2022385] Cathepsin G hydrolyzes angiotensin-(1-10) (angiotensin I) to...

Referrals

(hasEvent)	[Pathway:R-HSA-2022377] Metabolism of Angiotensinogen to Angiotensins
(precedingEvent)	[Reaction:R-HSA-2022399] ENPEP:Zn2+ hydrolyzes AGT(25-32) (Angiotensin-(1-8)) to AGT(26-32) (Angiotensin-(2-8)) [BlackBoxEvent:R-HSA-9944540] AGT(25-32) is decarboxylated to yield 1-Ala-AGT(25-32) (des(Asp1)-(Ala1)-Ang II, Angiotensin A) [Reaction:R-HSA-2022379] ACE2(18-805):Zn2+ hydrolyzes AGT(25-32) (Angiotensin-(1-8)) to AGT(25-31) (Angiotensin-(1-7))

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