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Schema
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Reaction
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Entries
Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))
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authored
[InstanceEdit:1998760] May, B, 2011-11-19
catalystActivity
[CatalystActivity:2065398] metallodipeptidase activity of ACE(30-1232):Zn2+ [extracellular region]
catalystActivityReference
[CatalystActivityReference:9643114] metallodipeptidase activity of ACE(30-1232):Zn2+ [extracellular region] Angiotensin I-converting enzyme mutation (Trp1197Stop) causes a dramatic increase in blood ACE
category
transition
compartment
[Compartment:984] extracellular region
created
[InstanceEdit:2065361] May, B, 2012-01-21
dbId
2065355
displayName
Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))
edited
[InstanceEdit:1998760] May, B, 2011-11-19
eventOf
[Pathway:R-HSA-2022377] Metabolism of Angiotensinogen to Angiotensins - Homo sapiens
followingEvent
[Reaction:R-HSA-9615348] AGT(25-32) binds to AGTR2 - Homo sapiens
[Reaction:R-HSA-374173] AGT(25-32) binds to AGTR1 - Homo sapiens
[Reaction:R-HSA-2022399] ENPEP:Zn2+ hydrolyzes AGT(25-32) (Angiotensin-(1-8)) to AGT(26-32) (Angiotensin-(2-8)) - Homo sapiens
[BlackBoxEvent:R-HSA-9944540] AGT(25-32) is decarboxylated to yield 1-Ala-AGT(25-32) (des(Asp1)-(Ala1)-Ang II, Angiotensin A) - Homo sapiens
[Reaction:R-HSA-2022379] ACE2(18-805):Zn2+ hydrolyzes AGT(25-32) (Angiotensin-(1-8)) to AGT(25-31) (Angiotensin-(1-7)) - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:172124] angiotensin maturation
input
[EntityWithAccessionedSequence:R-HSA-2022346] AGT(25-34) [extracellular region]
[SimpleEntity:R-ALL-109276] H2O [extracellular region]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:2065409] Expression and characterization of recombinant human angiotensin I-converting enzyme. Evidence for a C-terminal transmembrane anchor and for a proteolytic processing of the secreted recombinant and plasma enzymes
[LiteratureReference:2065402] The two homologous domains of human angiotensin I-converting enzyme are both catalytically active
[LiteratureReference:2065394] Purification of angiotensin-converting enzyme from human intestine
[LiteratureReference:2065382] Purification of human lung angiotensin-converting enzyme
[LiteratureReference:2065372] Rapid affinity chromatographic purification of human lung and kidney angiotensin-converting enzyme with the novel N-carboxyalkyl dipeptide inhibitor N-[1(S)-carboxy-5-aminopentyl]glycylglycine
[LiteratureReference:2065397] Purification and characterization of human converting enzyme (kininase II)
[LiteratureReference:2065388] Mixed-type inhibition of pulmonary angiotensin I-converting enzyme by captopril, enalaprilat and ramiprilat
[LiteratureReference:2028297] Crystal structure of the human angiotensin-converting enzyme-lisinopril complex
maxDepth
1
modified
[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name
Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))
Secreted Angiotensin-converting Enzyme Hydrolyzes Angiotensin I to Yield Angiotensin II
orthologousEvent
[Reaction:R-DME-2065355] Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Drosophila melanogaster
[Reaction:R-GGA-2065355] Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Gallus gallus
[Reaction:R-XTR-2065355] Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Xenopus tropicalis
[Reaction:R-DRE-2065355] Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Danio rerio
[Reaction:R-SSC-2065355] Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Sus scrofa
[Reaction:R-BTA-2065355] Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Bos taurus
[Reaction:R-CFA-2065355] Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Canis familiaris
[Reaction:R-RNO-2065355] Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Rattus norvegicus
[Reaction:R-MMU-2065355] Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Mus musculus
output
[EntityWithAccessionedSequence:R-HSA-374187] AGT(25-32) [extracellular region]
precedingEvent
[Reaction:R-HSA-2022412] Renin hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) - Homo sapiens
[Reaction:R-HSA-2022403] Renin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) - Homo sapiens
[Reaction:R-HSA-2065357] Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10)) - Homo sapiens
regulatedBy
[PositiveRegulation:R-HSA-2065425] Positive regulation by 'Cl- [extracellular region]'
[NegativeRegulation:9614930] Negative regulation by 'ACEIs:ACE(30-1232) [extracellular region]'
releaseDate
2012-09-18
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2426575] Joseph, J, 2012-08-06
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-2065355
summation
[Summation:2065403] Secreted angiotensin-converting enzyme (ACE) cleaves 2 amino...
updateTrackers
[UpdateTracker:9779061] Update Tracker - [Reaction:2065355] Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) - v66:[add_removeRegulator]
Referrals
(updatedInstance)
[UpdateTracker:9779061] Update Tracker - [Reaction:2065355] Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) - v66:[add_removeRegulator]
(hasEvent)
[Pathway:R-HSA-2022377] Metabolism of Angiotensinogen to Angiotensins
(precedingEvent)
[Reaction:R-HSA-2022399] ENPEP:Zn2+ hydrolyzes AGT(25-32) (Angiotensin-(1-8)) to AGT(26-32) (Angiotensin-(2-8))
[BlackBoxEvent:R-HSA-9944540] AGT(25-32) is decarboxylated to yield 1-Ala-AGT(25-32) (des(Asp1)-(Ala1)-Ang II, Angiotensin A)
[Reaction:R-HSA-2022379] ACE2(18-805):Zn2+ hydrolyzes AGT(25-32) (Angiotensin-(1-8)) to AGT(25-31) (Angiotensin-(1-7))
[Reaction:R-HSA-9615348] AGT(25-32) binds to AGTR2
[Reaction:R-HSA-374173] AGT(25-32) binds to AGTR1
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