Reactome | ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))

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ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) Show undefined attributes

authored	[InstanceEdit:1998760] May, B, 2011-11-19
catalystActivity	[CatalystActivity:2022372] metallodipeptidase activity of ACE(30-1306):Zn2+ [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9644105] metallodipeptidase activity of ACE(30-1306):Zn2+ [plasma membrane] Catalysis of angiotensin I hydrolysis by human angiotensin-converting enzyme: effect of chloride and pH
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:2022406] May, B, 2011-11-29
dbId	2022405
displayName	ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))
edited	[InstanceEdit:1998760] May, B, 2011-11-19
eventOf	[Pathway:R-HSA-2022377] Metabolism of Angiotensinogen to Angiotensins - Homo sapiens
followingEvent	[Reaction:R-HSA-2022399] ENPEP:Zn2+ hydrolyzes AGT(25-32) (Angiotensin-(1-8)) to AGT(26-32) (Angiotensin-(2-8)) - Homo sapiens [BlackBoxEvent:R-HSA-9944540] AGT(25-32) is decarboxylated to yield 1-Ala-AGT(25-32) (des(Asp1)-(Ala1)-Ang II, Angiotensin A) - Homo sapiens [Reaction:R-HSA-2022379] ACE2(18-805):Zn2+ hydrolyzes AGT(25-32) (Angiotensin-(1-8)) to AGT(25-31) (Angiotensin-(1-7)) - Homo sapiens [Reaction:R-HSA-9615348] AGT(25-32) binds to AGTR2 - Homo sapiens [Reaction:R-HSA-374173] AGT(25-32) binds to AGTR1 - Homo sapiens [Reaction:R-HSA-9944515] AGT(25-31) binds MAS1 - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:172124] angiotensin maturation
input	[EntityWithAccessionedSequence:R-HSA-2022346] AGT(25-34) [extracellular region] [SimpleEntity:R-ALL-109276] H2O [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2022269] Catalysis of angiotensin I hydrolysis by human angiotensin-converting enzyme: effect of chloride and pH [LiteratureReference:2065402] The two homologous domains of human angiotensin I-converting enzyme are both catalytically active [LiteratureReference:2065409] Expression and characterization of recombinant human angiotensin I-converting enzyme. Evidence for a C-terminal transmembrane anchor and for a proteolytic processing of the secreted recombinant and plasma enzymes [LiteratureReference:2065394] Purification of angiotensin-converting enzyme from human intestine [LiteratureReference:2065382] Purification of human lung angiotensin-converting enzyme [LiteratureReference:2065372] Rapid affinity chromatographic purification of human lung and kidney angiotensin-converting enzyme with the novel N-carboxyalkyl dipeptide inhibitor N-[1(S)-carboxy-5-aminopentyl]glycylglycine [LiteratureReference:2065397] Purification and characterization of human converting enzyme (kininase II) [LiteratureReference:2065388] Mixed-type inhibition of pulmonary angiotensin I-converting enzyme by captopril, enalaprilat and ramiprilat [LiteratureReference:2028297] Crystal structure of the human angiotensin-converting enzyme-lisinopril complex [LiteratureReference:2065384] Purification and characterization of recombinant human testis angiotensin-converting enzyme expressed in Chinese hamster ovary cells
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) Angiotensin-converting Enzyme Hydrolyzes Angiotensin I to Yield Angiotensin II
orthologousEvent	[Reaction:R-DME-2022405] ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Drosophila melanogaster [Reaction:R-GGA-2022405] ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Gallus gallus [Reaction:R-XTR-2022405] ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Xenopus tropicalis [Reaction:R-DRE-2022405] ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Danio rerio [Reaction:R-SSC-2022405] ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Sus scrofa [Reaction:R-BTA-2022405] ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Bos taurus [Reaction:R-CFA-2022405] ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Canis familiaris [Reaction:R-RNO-2022405] ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Rattus norvegicus [Reaction:R-MMU-2022405] ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-374187] AGT(25-32) [extracellular region]
precedingEvent	[Reaction:R-HSA-2022412] Renin hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) - Homo sapiens [Reaction:R-HSA-2022403] Renin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) - Homo sapiens [Reaction:R-HSA-2065357] Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10)) - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-2022391] Positive regulation by 'Cl- [extracellular region]'
releaseDate	2012-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2426575] Joseph, J, 2012-08-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2022405
summation	[Summation:2022402] Angiotensin-converting enzyme (ACE) hydrolyzes angiotensin-(...
updateTrackers	[UpdateTracker:9779136] Update Tracker - [Reaction:2022405] ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) - v66:[removeRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9779136] Update Tracker - [Reaction:2022405] ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) - v66:[removeRegulator]
(hasEvent)	[Pathway:R-HSA-2022377] Metabolism of Angiotensinogen to Angiotensins
(precedingEvent)	[Reaction:R-HSA-2022399] ENPEP:Zn2+ hydrolyzes AGT(25-32) (Angiotensin-(1-8)) to AGT(26-32) (Angiotensin-(2-8)) [BlackBoxEvent:R-HSA-9944540] AGT(25-32) is decarboxylated to yield 1-Ala-AGT(25-32) (des(Asp1)-(Ala1)-Ang II, Angiotensin A) [Reaction:R-HSA-9944515] AGT(25-31) binds MAS1 [Reaction:R-HSA-2022379] ACE2(18-805):Zn2+ hydrolyzes AGT(25-32) (Angiotensin-(1-8)) to AGT(25-31) (Angiotensin-(1-7)) [Reaction:R-HSA-9615348] AGT(25-32) binds to AGTR2 [Reaction:R-HSA-374173] AGT(25-32) binds to AGTR1

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