Secreted ACE:Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)

Stable Identifier
Reaction [transition]
Homo sapiens
Secreted Angiotensin-converting Enzyme Hydrolyzes Angiotensin I to Yield Angiotensin II
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Secreted angiotensin-converting enzyme (ACE) cleaves 2 amino acid residues from the C-terminus of angiotensin-(1-10) (angiotensin I) to yield angiotensin-(1-8) (angiotensin II) (Wei et al. 1991). This reaction is inhibited by drugs used to treat hypertension (angiotensin converting enzyme inhibitors, ACEI) including captopril (Gronhagen-Riska and Fyhrquist 1980, Stewart et al. 1981, Ehlers et al. 1986, Hayakari et al. 1989, Wei et al. 1991, Baudin and Beneteau-Burnat 1999), enalaprilat (metablized from the prodrug enalapril, Wei et al. 1991, Baudin and Beneteau-Burnat 1999), lisinopril ( Ehlers et al. 1991, Natesh et al. 2003), and ramiprilat (metabolized from the prodrug ramipril, Baudin and Beneteau-Burnat 1999). ACE is secreted ("shed") from membranes of endothelial cells by cleavage in the C-terminal region that removes the membrane anchor.
Literature References
PubMed ID Title Journal Year
1848554 Expression and characterization of recombinant human angiotensin I-converting enzyme. Evidence for a C-terminal transmembrane anchor and for a proteolytic processing of the secreted recombinant and plasma enzymes

Wei, L, Clauser, E, Corvol, P, Soubrier, F, Michaud, A, Alhenc-Gelas, F

J Biol Chem 1991
2558510 Purification of angiotensin-converting enzyme from human intestine

Amano, K, Hayakari, M, Murakami, S, Izumi, H

Adv Exp Med Biol 1989
6270633 Purification and characterization of human converting enzyme (kininase II)

Weare, JA, Erdös, EG, Stewart, TA

Peptides 1981
6269175 Purification of human lung angiotensin-converting enzyme

Fyhrquist, F, Grönhagen-Riska, C

Scand J Clin Lab Invest 1980
12540854 Crystal structure of the human angiotensin-converting enzyme-lisinopril complex

Acharya, KR, Sturrock, ED, Schwager, SL, Natesh, R

Nature 2003
1851160 The two homologous domains of human angiotensin I-converting enzyme are both catalytically active

Wei, L, Clauser, E, Corvol, P, Alhenc-Gelas, F

J Biol Chem 1991
10536878 Mixed-type inhibition of pulmonary angiotensin I-converting enzyme by captopril, enalaprilat and ramiprilat

Bénéteau-Burnat, B, Baudin, B

J Enzyme Inhib 1999
3017438 Rapid affinity chromatographic purification of human lung and kidney angiotensin-converting enzyme with the novel N-carboxyalkyl dipeptide inhibitor N-[1(S)-carboxy-5-aminopentyl]glycylglycine

Kirsch, RE, Maeder, DL, Ehlers, MR

Biochim Biophys Acta 1986
Event Information
Go Biological Process
Catalyst Activity

metallodipeptidase activity of ACE(30-1232):Zn2+ [extracellular region]

This event is regulated
Positively by
Orthologous Events
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