Reactome | Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))

Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))

Stable Identifier

R-HSA-2065355

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Secreted Angiotensin-converting Enzyme Hydrolyzes Angiotensin I to Yield Angiotensin II

ReviewStatus

5/5

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Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))

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Secreted angiotensin-converting enzyme (ACE) cleaves 2 amino acid residues from the C-terminus of angiotensin-(1-10) (angiotensin I) to yield angiotensin-(1-8) (angiotensin II) (Wei et al. 1991). This reaction is inhibited by drugs used to treat hypertension (angiotensin converting enzyme inhibitors, ACEI) including captopril (Gronhagen-Riska and Fyhrquist 1980, Stewart et al. 1981, Ehlers et al. 1986, Hayakari et al. 1989, Wei et al. 1991, Baudin and Beneteau-Burnat 1999), enalaprilat (metablized from the prodrug enalapril, Wei et al. 1991, Baudin and Beneteau-Burnat 1999), lisinopril ( Ehlers et al. 1991, Natesh et al. 2003), and ramiprilat (metabolized from the prodrug ramipril, Baudin and Beneteau-Burnat 1999). ACE is secreted ("shed") from membranes of endothelial cells by cleavage in the C-terminal region that removes the membrane anchor.

Literature References

PubMed ID	Title	Journal	Year
1848554	Expression and characterization of recombinant human angiotensin I-converting enzyme. Evidence for a C-terminal transmembrane anchor and for a proteolytic processing of the secreted recombinant and plasma enzymes Wei, L, Alhenc-Gelas, F, Soubrier, F, Michaud, A, Corvol, P, Clauser, E	J Biol Chem	1991
2558510	Purification of angiotensin-converting enzyme from human intestine Hayakari, M, Amano, K, Izumi, H, Murakami, S	Adv Exp Med Biol	1989
6270633	Purification and characterization of human converting enzyme (kininase II) Stewart, TA, Weare, JA, Erdös, EG	Peptides	1981
6269175	Purification of human lung angiotensin-converting enzyme Grönhagen-Riska, C, Fyhrquist, F	Scand J Clin Lab Invest	1980
12540854	Crystal structure of the human angiotensin-converting enzyme-lisinopril complex Natesh, R, Schwager, SL, Sturrock, ED, Acharya, KR	Nature	2003
1851160	The two homologous domains of human angiotensin I-converting enzyme are both catalytically active Wei, L, Alhenc-Gelas, F, Corvol, P, Clauser, E	J Biol Chem	1991
10536878	Mixed-type inhibition of pulmonary angiotensin I-converting enzyme by captopril, enalaprilat and ramiprilat Baudin, B, Bénéteau-Burnat, B	J Enzyme Inhib	1999
3017438	Rapid affinity chromatographic purification of human lung and kidney angiotensin-converting enzyme with the novel N-carboxyalkyl dipeptide inhibitor N-[1(S)-carboxy-5-aminopentyl]glycylglycine Ehlers, MR, Maeder, DL, Kirsch, RE	Biochim Biophys Acta	1986