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Schema
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Reaction
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Entries
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor
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authored
[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
catalystActivity
[CatalystActivity:204987] guanyl-nucleotide exchange factor activity of GEFs [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created
[InstanceEdit:204953] Jassal, B, 2007-12-06 11:10:12
dbId
205039
displayName
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor
edited
[InstanceEdit:350668] Jassal, B, 2008-05-20 12:26:36
eventOf
[Pathway:R-HSA-193648] NRAGE signals death through JNK - Homo sapiens
input
[SimpleEntity:R-ALL-29438] GTP [cytosol]
[Complex:R-HSA-217287] RAC1:GDP [plasma membrane]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:216352] Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis
maxDepth
1
modified
[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor
orthologousEvent
[Reaction:R-DRE-205039] p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor - Danio rerio
[Reaction:R-SCE-205039] p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor - Saccharomyces cerevisiae
[Reaction:R-DDI-205039] p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor - Dictyostelium discoideum
[Reaction:R-CEL-205039] p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor - Caenorhabditis elegans
[Reaction:R-DME-205039] p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor - Drosophila melanogaster
[Reaction:R-GGA-205039] p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor - Gallus gallus
[Reaction:R-SSC-205039] p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor - Sus scrofa
[Reaction:R-CFA-205039] p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor - Canis familiaris
[Reaction:R-RNO-205039] p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor - Rattus norvegicus
[Reaction:R-MMU-205039] p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor - Mus musculus
output
[SimpleEntity:R-ALL-29420] GDP [cytosol]
[Complex:R-HSA-217289] RAC1:GTP [plasma membrane]
releaseDate
2008-06-30
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:350667] Friedman, WJ, 2008-05-20 12:23:46
[InstanceEdit:351795] Chao, MV, 2008-05-28 09:46:01
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-205039
summation
[Summation:204985] Following NGF binding, p75NTR activates the RAC (Ras-related...
updateTrackers
[UpdateTracker:9791635] Update Tracker - [Reaction:205039] p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor - v28:[addInput, addOutput]
Referrals
(updatedInstance)
[UpdateTracker:9791635] Update Tracker - [Reaction:205039] p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor - v28:[addInput, addOutput]
(hasEvent)
[Pathway:R-HSA-193648] NRAGE signals death through JNK
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