Reactome | p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor

Schema > Reaction > Entries

p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor Show undefined attributes

catalystActivity	[CatalystActivity:10576961] guanyl-nucleotide exchange factor activity of GEFs [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10576963
displayName	p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor
eventOf	[Pathway:R-DRE-193648] NRAGE signals death through JNK - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-205039] p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-DRE-217287] RAC1:GDP [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-DRE-217289] RAC1:GTP [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-205039
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-193648] NRAGE signals death through JNK
(inferredTo)	[Reaction:R-HSA-205039] p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor

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