Reactome | RAC1:GTP [plasma membrane]

Schema > Complex > Entries

RAC1:GTP [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-389780] RAC1-GTP:p-S144,T423-PAK1 [plasma membrane] - Homo sapiens [Complex:R-HSA-3928560] EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] - Homo sapiens [Complex:R-NUL-350936] Fz1:Dvl2:Rac1:GTP [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-NUL-350365] Dvl2 binds to Rac1:GTP - Homo sapiens [Reaction:R-HSA-3928619] PAK1 binds RAC1:GTP - Homo sapiens [Reaction:R-HSA-3928619] PAK1 binds RAC1:GTP - Homo sapiens
created	[InstanceEdit:217304] Jassal, B, 2008-03-26 11:46:08
dbId	217289
deleted	[Deleted:8943474] Deletion of instance: 2316448
displayName	RAC1:GTP [plasma membrane]
hasComponent	[EntityWithAccessionedSequence:R-HSA-2316446] GGC-PalmC-RAC1 [plasma membrane] [SimpleEntity:R-ALL-29438] GTP [cytosol]
inDisease	false
includedLocation	[Compartment:70101] cytosol
inferredTo	[Complex:R-MMU-217289] RAC1:GTP [plasma membrane] - Mus musculus [Complex:R-RNO-217289] RAC1:GTP [plasma membrane] - Rattus norvegicus [Complex:R-CFA-217289] RAC1:GTP [plasma membrane] - Canis familiaris [Complex:R-BTA-217289] RAC1:GTP [plasma membrane] - Bos taurus [Complex:R-SSC-217289] RAC1:GTP [plasma membrane] - Sus scrofa [Complex:R-DRE-217289] RAC1:GTP [plasma membrane] - Danio rerio [Complex:R-XTR-217289] RAC1:GTP [plasma membrane] - Xenopus tropicalis [Complex:R-GGA-217289] RAC1:GTP [plasma membrane] - Gallus gallus [Complex:R-DME-217289] RAC1:GTP [plasma membrane] - Drosophila melanogaster [Complex:R-CEL-217289] RAC1:GTP [plasma membrane] - Caenorhabditis elegans [Complex:R-DDI-217289] RAC1:GTP [plasma membrane] - Dictyostelium discoideum [Complex:R-SCE-217289] RAC1:GTP [plasma membrane] - Saccharomyces cerevisiae
isRequired	[Requirement:R-HSA-1050113] Requirement by 'RAC1:GTP [plasma membrane]'
literatureReference	[LiteratureReference:2316440] A palmitoylation switch mechanism regulates Rac1 function and membrane organization
maxDepth	2
modified	[InstanceEdit:8979622] D'Eustachio, Peter, 2017-02-27
name	RAC1:GTP
positivelyRegulates	[PositiveRegulation:R-HSA-1458541] Positive regulation by 'RAC1:GTP [plasma membrane]' [Requirement:R-HSA-1050113] Requirement by 'RAC1:GTP [plasma membrane]'
producedByEvent	[Reaction:R-HSA-205039] p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor - Homo sapiens [Reaction:R-HSA-3928612] KALRN exchanges GTP for GDP on RAC1, activating it - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-217289
updateTrackers	[UpdateTracker:9895118] Update Tracker - [Complex:217289] RAC1:GTP [plasma membrane] - v59:[addLiteratureReference] [UpdateTracker:9878208] Update Tracker - [Complex:217289] RAC1:GTP [plasma membrane] - v44:[add_removeHasComponent, modifyName] [UpdateTracker:9895863] Update Tracker - [Complex:217289] RAC1:GTP [plasma membrane] - v60:[add_removeHasComponent]

Referrals

(updatedInstance)	[UpdateTracker:9895118] Update Tracker - [Complex:217289] RAC1:GTP [plasma membrane] - v59:[addLiteratureReference] [UpdateTracker:9878208] Update Tracker - [Complex:217289] RAC1:GTP [plasma membrane] - v44:[add_removeHasComponent, modifyName] [UpdateTracker:9895863] Update Tracker - [Complex:217289] RAC1:GTP [plasma membrane] - v60:[add_removeHasComponent]
(replacementInstances)	[Deleted:8943474] Deletion of instance: 2316448
(hasComponent)	[Complex:R-NUL-350936] Fz1:Dvl2:Rac1:GTP [plasma membrane] [Complex:R-HSA-389780] RAC1-GTP:p-S144,T423-PAK1 [plasma membrane] [Complex:R-HSA-3928523] RAC1:GTP:PAK1 dimer:RAC1:GTP [plasma membrane] [Complex:R-HSA-3928560] EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane]
(input)	[Reaction:R-NUL-350365] Dvl2 binds to Rac1:GTP [Reaction:R-HSA-3928619] PAK1 binds RAC1:GTP
(regulator)	[PositiveRegulation:R-HSA-1458541] Positive regulation by 'RAC1:GTP [plasma membrane]' [Requirement:R-HSA-1050113] Requirement by 'RAC1:GTP [plasma membrane]'
(output)	[Reaction:R-HSA-3928612] KALRN exchanges GTP for GDP on RAC1, activating it [Reaction:R-HSA-205039] p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor

Cite Us!