p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor

Stable Identifier
R-HSA-205039
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Following NGF binding, p75NTR activates the RAC (Ras-related C3 botulinum toxin substrate) GTPase.

Literature References
PubMed ID Title Journal Year
11756498 Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis

Harrington, AW, Kim, JY, Yoon, SO

J Neurosci 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of GEFs [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created