p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor

Stable Identifier
R-HSA-205039
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor
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Following NGF binding, p75NTR activates the RAC (Ras-related C3 botulinum toxin substrate) GTPase.

Literature References
PubMed ID Title Journal Year
11756498 Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis

Harrington, AW, Kim, JY, Yoon, SO

J Neurosci 2002
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of GEFs [cytosol]
Physical Entity
GEFs [cytosol]
Activity
guanyl-nucleotide exchange factor activity (0005085)
Orthologous Events
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Caenorhabditis elegans)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Danio rerio)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Dictyostelium discoideum)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Drosophila melanogaster)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Gallus gallus)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Mus musculus)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Rattus norvegicus)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Sus scrofa)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Xenopus tropicalis)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Friedman, WJ  (2008-05-20)
Chao, MV  (2008-05-28)
Created
Jassal, B  (2007-12-06)
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