Reactome | CHST2,3,5,6 transfer sulfate to GlcNAc on keratan chain

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CHST2,3,5,6 transfer sulfate to GlcNAc on keratan chain Show undefined attributes

authored	[InstanceEdit:2022912] Jassal, B, 2011-12-01
catalystActivity	[CatalystActivity:2046153] N-acetylglucosamine 6-O-sulfotransferase activity of CHST2,3,5,6 [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:2046181] Jassal, B, 2012-01-11
crossReference	[DatabaseIdentifier:9941347] RHEA:67857
dbId	2046222
diseaseReaction	[FailedReaction:R-HSA-3656269] Defective CHST6 does not transfer SO4(2-) to GlcNAc residues on keratan-PG - Homo sapiens
displayName	CHST2,3,5,6 transfer sulfate to GlcNAc on keratan chain
edited	[InstanceEdit:2022912] Jassal, B, 2011-12-01
eventOf	[Pathway:R-HSA-2022854] Keratan sulfate biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-2046175] CHST1 transfers sulfate to Gal on keratan chain - Homo sapiens
input	[DefinedSet:R-HSA-2046203] Keratan(4)-PG [Golgi lumen] [SimpleEntity:R-ALL-741440] PAPS [Golgi lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2161451] Functional expression and genomic structure of human N-acetylglucosamine-6-O-sulfotransferase that transfers sulfate to beta-N-acetylglucosamine at the nonreducing end of an N-acetyllactosamine sequence [LiteratureReference:2161440] Cloning and characterization of a mammalian N-acetylglucosamine-6-sulfotransferase that is highly restricted to intestinal tissue [LiteratureReference:2161411] Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	CHST2,3,5,6 transfer sulfate to GlcNAc on keratan chain Sulfation of GlcNAc residues on Keratan-PG forms KSPG
orthologousEvent	[Reaction:R-DME-2046222] CHST2,3,5,6 transfer sulfate to GlcNAc on keratan chain - Drosophila melanogaster [Reaction:R-GGA-2046222] CHST2,3,5,6 transfer sulfate to GlcNAc on keratan chain - Gallus gallus [Reaction:R-XTR-2046222] CHST2,3,5,6 transfer sulfate to GlcNAc on keratan chain - Xenopus tropicalis [Reaction:R-DRE-2046222] CHST2,3,5,6 transfer sulfate to GlcNAc on keratan chain - Danio rerio [Reaction:R-SSC-2046222] CHST2,3,5,6 transfer sulfate to GlcNAc on keratan chain - Sus scrofa [Reaction:R-BTA-2046222] CHST2,3,5,6 transfer sulfate to GlcNAc on keratan chain - Bos taurus [Reaction:R-CFA-2046222] CHST2,3,5,6 transfer sulfate to GlcNAc on keratan chain - Canis familiaris [Reaction:R-RNO-2046222] CHST2,3,5,6 transfer sulfate to GlcNAc on keratan chain - Rattus norvegicus [Reaction:R-MMU-2046222] CHST2,3,5,6 transfer sulfate to GlcNAc on keratan chain - Mus musculus
output	[SimpleEntity:R-ALL-425969] H+ [Golgi lumen] [DefinedSet:R-HSA-2046166] KSPG(1) [Golgi lumen] [SimpleEntity:R-ALL-742343] PAP [Golgi lumen]
precedingEvent	[Reaction:R-HSA-2046285] ST3GAL1-4,6 optionally cap keratan chain - Homo sapiens [Reaction:R-HSA-741449] SLC35B2,3 exchange cytosolic PAPS with Golgi PAP - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28 [InstanceEdit:9941989] D'Eustachio, Peter, 2025-03-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2046222
summation	[Summation:2161467] Carbohydrate sulfotransferases 2, 3, 5 and 6 (CHST2, 3, 5 an...
updateTrackers	[UpdateTracker:9786330] Update Tracker - [Reaction:2046222] CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG - v50:[modifyText] [UpdateTracker:9953573] Update Tracker - [Reaction:2046222] CHST2,3,5,6 transfer sulfate to GlcNAc on keratan chain - v93:[modifyText, removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9786330] Update Tracker - [Reaction:2046222] CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG - v50:[modifyText] [UpdateTracker:9953573] Update Tracker - [Reaction:2046222] CHST2,3,5,6 transfer sulfate to GlcNAc on keratan chain - v93:[modifyText, removeOutput]
(normalReaction)	[FailedReaction:R-HSA-3656269] Defective CHST6 does not transfer SO4(2-) to GlcNAc residues on keratan-PG
(hasEvent)	[Pathway:R-HSA-2022854] Keratan sulfate biosynthesis
(precedingEvent)	[Reaction:R-HSA-2046175] CHST1 transfers sulfate to Gal on keratan chain

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