Reactome | CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG

CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG

Stable Identifier

R-HSA-2046222

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, Golgi lumen

Synonyms

Sulfation of GlcNAc residues on Keratan-PG forms KSPG

ReviewStatus

5/5

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CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG

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Carbohydrate sulfotransferases 2, 5 and 6 (CHST2, 5 and 6) catalyze the transfer of sulfate to position 6 of non-reducing ends of N-acetylglucosamine (GlcNAc) residues within keratan-like molecules (Sakaguchi et al. 2000, Lee et al. 1999, Akama et al. 2002). Keratan(4)-PG represents keratan before sulfation has occurred.

Literature References

PubMed ID	Title	Journal	Year
11042394	Functional expression and genomic structure of human N-acetylglucosamine-6-O-sulfotransferase that transfers sulfate to beta-N-acetylglucosamine at the nonreducing end of an N-acetyllactosamine sequence Kitagawa, H, Sakaguchi, H, Sugahara, K	Biochim Biophys Acta	2000
12218059	Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate Misra, AK, Hindsgaul, O, Akama, TO, Fukuda, MN	J Biol Chem	2002
10491328	Cloning and characterization of a mammalian N-acetylglucosamine-6-sulfotransferase that is highly restricted to intestinal tissue Bhakta, S, Hemmerich, S, Lee, JK, Rosen, SD	Biochem Biophys Res Commun	1999