Reactome | Activation of alpha-linolenic acid to alpha-linolenoyl-CoA

Activation of alpha-linolenic acid to alpha-linolenoyl-CoA

Stable Identifier

R-HSA-2046085

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, endoplasmic reticulum lumen

ReviewStatus

5/5

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Activation of alpha-linolenic acid to alpha-linolenoyl-CoA

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In the first step the precursor apha-linolenic (9,12,15-18:3(n-3)) acid is activated to a high energy form known as alpha-linolenoyl-CoA (9Z,12Z,15Z-octadecatrienoyl-CoA) by the iron enzyme long-chain-fatty-acid-CoA-ligase (acyl-CoA synthetase 1, ACSL1) and coenzyme A.

Literature References

PubMed ID	Title	Journal	Year
	Nutrient Metabolism Biosketch, M		2003
7061494	Discovery of an arachidonoyl coenzyme A synthetase in human platelets Wilson, DB, Majerus, PW, Prescott, SM	J Biol Chem	1982