Activation of alpha-linolenic acid to alpha-linolenoyl-CoA

Stable Identifier
R-HSA-2046085
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, endoplasmic reticulum lumen
ReviewStatus
5/5
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Activation of alpha-linolenic acid to alpha-linolenoyl-CoA
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
In the first step the precursor apha-linolenic (9,12,15-18:3(n-3)) acid is activated to a high energy form known as alpha-linolenoyl-CoA (9Z,12Z,15Z-octadecatrienoyl-CoA) by the iron enzyme long-chain-fatty-acid-CoA-ligase (acyl-CoA synthetase 1, ACSL1) and coenzyme A.
Literature References
PubMed ID Title Journal Year
  Nutrient Metabolism

Biosketch, M

  2003
7061494 Discovery of an arachidonoyl coenzyme A synthetase in human platelets

Wilson, DB, Prescott, SM, Majerus, PW

J Biol Chem 1982
Participants
Input
Output
Participates
as an event of
Catalyst Activity

long-chain fatty acid-CoA ligase activity of ACSL1 [endoplasmic reticulum membrane]

Physical Entity
ACSL1 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
long-chain fatty acid-CoA ligase activity (GO:0004467)
Orthologous Events
Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Bos taurus)
Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Caenorhabditis elegans)
Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Canis familiaris)
Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Danio rerio)
Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Dictyostelium discoideum)
Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Gallus gallus)
Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Mus musculus)
Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Plasmodium falciparum)
Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Rattus norvegicus)
Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Saccharomyces cerevisiae)
Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Sus scrofa)
Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Xenopus tropicalis)
Cross References
RHEA
Authored
Garapati, P V  (2012-01-11)
Created
Garapati, P V  (2012-01-11)
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