Reactome | PDP1,2 dephosphorylate p-lipo-PDH

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PDP1,2 dephosphorylate p-lipo-PDH Show undefined attributes

authored	[InstanceEdit:204185] Gopinathrao, G, 2007-11-26 20:29:38
catalystActivity	[CatalystActivity:204160] [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity of PDP [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9644040] [pyruvate dehydrogenase (lipoamide)] phosphatase activity of PDP [mitochondrial matrix] Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulation
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:204156] Gopinathrao, G, 2007-11-26 19:47:38
crossReference	[DatabaseIdentifier:9861815] RHEA:12670
dbId	204169
displayName	PDP1,2 dephosphorylate p-lipo-PDH
eventOf	[Pathway:R-HSA-204174] Regulation of pyruvate dehydrogenase (PDH) complex - Homo sapiens
followingEvent	[Reaction:R-HSA-203946] PDK isozymes phosphorylate PDHC subunit E1 - Homo sapiens [Reaction:R-HSA-9861667] DLAT trimer transfers acetyl to CoA - Homo sapiens [Reaction:R-HSA-9861734] PDH E1 decarboxylates PYR, transferring acetyl to DLAT - Homo sapiens [Reaction:R-HSA-9861616] DLD dimer dehydrogenates dihydrolipoyl - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [Complex:R-HSA-210342] p-lipo-PDH [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:210346] Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulation [LiteratureReference:210340] Cloning, expression, and properties of the regulatory subunit of bovine pyruvate dehydrogenase phosphatase [LiteratureReference:204177] Pyruvate dehydrogenase phosphatase deficiency: identification of the first mutation in two brothers and restoration of activity by protein complementation [LiteratureReference:204179] Crystal structure of pyruvate dehydrogenase phosphatase 1 and its functional implications [LiteratureReference:9861875] Pyruvate dehydrogenase phosphatase deficiency: orphan disease or an under-diagnosed condition?
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	PDP1,2 dephosphorylate p-lipo-PDH PDP-catalyzed dephosphorylation (activation) of phospho E1 alpha subunit Activation of PDC by dephosphorylation of phospho-E1 alpha component
orthologousEvent	[Reaction:R-DRE-204169] PDP1,2 dephosphorylate p-lipo-PDH - Danio rerio [Reaction:R-SSC-204169] PDP1,2 dephosphorylate p-lipo-PDH - Sus scrofa [Reaction:R-MMU-204169] PDP1,2 dephosphorylate p-lipo-PDH - Mus musculus [Reaction:R-GGA-204169] PDP1,2 dephosphorylate p-lipo-PDH - Gallus gallus [Reaction:R-XTR-204169] PDP1,2 dephosphorylate p-lipo-PDH - Xenopus tropicalis [Reaction:R-CEL-204169] PDP1,2 dephosphorylate p-lipo-PDH - Caenorhabditis elegans [Reaction:R-DME-204169] PDP1,2 dephosphorylate p-lipo-PDH - Drosophila melanogaster [Reaction:R-BTA-204169] PDP1,2 dephosphorylate p-lipo-PDH - Bos taurus [Reaction:R-CFA-204169] PDP1,2 dephosphorylate p-lipo-PDH - Canis familiaris [Reaction:R-RNO-204169] PDP1,2 dephosphorylate p-lipo-PDH - Rattus norvegicus
output	[Complex:R-HSA-70070] PDH complex [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-113548] Pi [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-203946] PDK isozymes phosphorylate PDHC subunit E1 - Homo sapiens
regulatedBy	[Requirement:R-HSA-210326] Requirement by 'Mg2+ [mitochondrial matrix]'
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:210329] D'Eustachio, P, 2008-01-11 20:49:08 [InstanceEdit:9862191] Hill, David P, 2024-02-23
revised	[InstanceEdit:450856] D'Eustachio, P, 2009-12-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-204169
summation	[Summation:204183] Pyruvate dehydrogenase phosphatase (PDP) in the mitochondria...
updateTrackers	[UpdateTracker:9864027] Update Tracker - [Reaction:204169] PDP1,2 dephosphorylate p-lipo-PDH - v88:[addLiteratureReference] [UpdateTracker:9791225] Update Tracker - [Reaction:204169] PDP dephosphorylates p-lipo-PDH - v32:[add_removeInput, add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9864027] Update Tracker - [Reaction:204169] PDP1,2 dephosphorylate p-lipo-PDH - v88:[addLiteratureReference] [UpdateTracker:9791225] Update Tracker - [Reaction:204169] PDP dephosphorylates p-lipo-PDH - v32:[add_removeInput, add_removeOutput, modifyText]
(hasEvent)	[Pathway:R-HSA-204174] Regulation of pyruvate dehydrogenase (PDH) complex
(precedingEvent)	[Reaction:R-HSA-203946] PDK isozymes phosphorylate PDHC subunit E1 [Reaction:R-HSA-9861667] DLAT trimer transfers acetyl to CoA [Reaction:R-HSA-9861734] PDH E1 decarboxylates PYR, transferring acetyl to DLAT [Reaction:R-HSA-9861616] DLD dimer dehydrogenates dihydrolipoyl

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