Reactome | Exportin complex translocates pre-miRNA to cytosol

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Exportin complex translocates pre-miRNA to cytosol Show undefined attributes

authored	[InstanceEdit:203918] Gopinathrao, G, May, B, 2007-11-18 23:55:40
catalystActivity	[CatalystActivity:209663] RNA transmembrane transporter activity of pre-miRNA:RAN:GTP:Exportin-5 [nucleoplasm]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:203816] Gopinathrao, G, 2007-11-18 23:55:40
dbId	203906
displayName	Exportin complex translocates pre-miRNA to cytosol
edited	[InstanceEdit:426448] May, B, 2009-06-16
eventOf	[Pathway:R-HSA-203927] MicroRNA (miRNA) biogenesis - Homo sapiens
followingEvent	[Reaction:R-HSA-5578717] BCDIN3D dimethylates 5' phosphate of pre-miR-145 - Homo sapiens [Reaction:R-HSA-203862] Dicer cleaves pre-miRNA to yield duplex miRNA - Homo sapiens
input	[Complex:R-HSA-209660] pre-miRNA:RAN:GTP:Exportin-5 [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:209654] Nuclear export of microRNA precursors [LiteratureReference:203875] Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs [LiteratureReference:209665] Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Exportin complex translocates pre-miRNA to cytosol
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [GenomeEncodedEntity:R-HSA-8963808] pre-microRNA [cytosol] [Complex:R-HSA-209672] RAN:GDP:Exportin-5 [cytosol]
precedingEvent	[Reaction:R-HSA-203922] Exportin-5 recognizes 3' overhang of pre-miRNA - Homo sapiens
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:212012] Karginov, F, Hannon, GJ, 2008-02-08 15:41:16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-203906
summation	[Summation:209657] Nuclear Export by Exportin-5. The pre-microRNA is bound by t...

Referrals

(precedingEvent)	[Reaction:R-HSA-5578717] BCDIN3D dimethylates 5' phosphate of pre-miR-145 [Reaction:R-HSA-203862] Dicer cleaves pre-miRNA to yield duplex miRNA
(hasEvent)	[Pathway:R-HSA-203927] MicroRNA (miRNA) biogenesis