Reactome | t(4;14) translocations of FGFR3

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t(4;14) translocations of FGFR3 Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2033516] Rothfels, K, 2012-01-09
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	2033515
disease	[Disease:1500689] cancer
displayName	t(4;14) translocations of FGFR3
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
eventOf	[Pathway:R-HSA-2033514] FGFR3 mutant receptor activation - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-2038386] Dimerization of FGFR3 t(4;14) translocation mutants - Homo sapiens [Reaction:R-HSA-2038387] Autocatalytic phosphorylation of FGFR3 t(4;14) translocation mutants - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:2033245] High incidence of translocations t(11;14)(q13;q32) and t(4;14)(p16;q32) in patients with plasma cell malignancies [LiteratureReference:2033248] Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3 [LiteratureReference:2033247] The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity [LiteratureReference:2032925] Deregulated FGFR3 mutants in multiple myeloma cell lines with t(4;14): comparative analysis of Y373C, K650E and the novel G384D mutations [LiteratureReference:2033241] Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice [LiteratureReference:2033244] The inhibitory anti-FGFR3 antibody, PRO-001, is cytotoxic to t(4;14) multiple myeloma cells [LiteratureReference:2033240] Expression of fibroblast growth factor and FGF-receptor family genes in human myeloma cells, including lines possessing t(4;14)(q16.3;q32. 3) and FGFR3 translocation [LiteratureReference:2033249] Mutation, SNP, and isoform analysis of fibroblast growth factor receptor 3 (FGFR3) in 150 newly diagnosed multiple myeloma patients [LiteratureReference:1637849] Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma
maxDepth	2
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	t(4;14) translocations of FGFR3
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2033515
summation	[Summation:2033513] Translocations which put the FGFR3 gene under the control of...

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[Pathway:R-HSA-2033514] FGFR3 mutant receptor activation

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