Reactome | Dimerization of FGFR3 t(4;14) translocation mutants

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Dimerization of FGFR3 t(4;14) translocation mutants Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2038389] Rothfels, K, 2012-01-09
dbId	2038386
disease	[Disease:1500689] cancer [Disease:1614388] multiple myeloma
displayName	Dimerization of FGFR3 t(4;14) translocation mutants
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5654493] gain_of_function of FGFR3 (4;14) translocation mutants [plasma membrane]
eventOf	[Pathway:R-HSA-2033515] t(4;14) translocations of FGFR3 - Homo sapiens
input	2 × [CandidateSet:R-HSA-2038374] FGFR3 (4;14) translocation mutants [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1637849] Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma [LiteratureReference:2033248] Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3 [LiteratureReference:2033245] High incidence of translocations t(11;14)(q13;q32) and t(4;14)(p16;q32) in patients with plasma cell malignancies [LiteratureReference:2033240] Expression of fibroblast growth factor and FGF-receptor family genes in human myeloma cells, including lines possessing t(4;14)(q16.3;q32. 3) and FGFR3 translocation [LiteratureReference:2033241] Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice [LiteratureReference:2032939] The myeloma-associated oncogene fibroblast growth factor receptor 3 is transforming in hematopoietic cells [LiteratureReference:2032925] Deregulated FGFR3 mutants in multiple myeloma cell lines with t(4;14): comparative analysis of Y373C, K650E and the novel G384D mutations
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Dimerization of FGFR3 t(4;14) translocation mutants
output	[CandidateSet:R-HSA-2038375] FGFR3 (4;14) translocation mutant dimers [plasma membrane]
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2038386
summation	[Summation:2065484] ~15% of multiple myelomas contain translocations that put th...

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[Pathway:R-HSA-2033515] t(4;14) translocations of FGFR3