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Entries
Autocatalytic phosphorylation of FGFR3 t(4;14) translocation mutants
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authored
[InstanceEdit:2105031] Rothfels, K, 2012-02-09
catalystActivity
[CatalystActivity:2038388] protein tyrosine kinase activity of FGFR3 (4;14) translocation mutant dimers [plasma membrane]
category
transition
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created
[InstanceEdit:2038389] Rothfels, K, 2012-01-09
dbId
2038387
disease
[Disease:1500689] cancer
[Disease:1614388] multiple myeloma
displayName
Autocatalytic phosphorylation of FGFR3 t(4;14) translocation mutants
edited
[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus
[EntityFunctionalStatus:5654462] gain_of_function of FGFR3 (4;14) translocation mutant dimers [plasma membrane]
eventOf
[Pathway:R-HSA-2033515] t(4;14) translocations of FGFR3 - Homo sapiens
input
12 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[CandidateSet:R-HSA-2038375] FGFR3 (4;14) translocation mutant dimers [plasma membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:1637849] Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma
[LiteratureReference:2032925] Deregulated FGFR3 mutants in multiple myeloma cell lines with t(4;14): comparative analysis of Y373C, K650E and the novel G384D mutations
[LiteratureReference:2032939] The myeloma-associated oncogene fibroblast growth factor receptor 3 is transforming in hematopoietic cells
[LiteratureReference:2065483] Targeting FGFR3 in multiple myeloma: inhibition of t(4;14)-positive cells by SU5402 and PD173074
[LiteratureReference:2033241] Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice
[LiteratureReference:2033244] The inhibitory anti-FGFR3 antibody, PRO-001, is cytotoxic to t(4;14) multiple myeloma cells
[LiteratureReference:2065481] NF449 is a novel inhibitor of fibroblast growth factor receptor 3 (FGFR3) signaling active in chondrocytes and multiple myeloma cells
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
Autocatalytic phosphorylation of FGFR3 t(4;14) translocation mutants
output
[CandidateSet:R-HSA-2038377] Activated FGFR3 t(4;14) translocation mutants [plasma membrane]
12 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
releaseDate
2012-06-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-2038387
summation
[Summation:2065487] Overexpression of WT FGFR3 is weakly transforming when expre...
Referrals
(hasEvent)
[Pathway:R-HSA-2033515] t(4;14) translocations of FGFR3
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