Reactome | FGFR3 mutant receptor activation

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FGFR3 mutant receptor activation Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:2033516] Rothfels, K, 2012-01-09
dbId	2033514
disease	[Disease:1500689] cancer [Disease:2032940] bone development disease
displayName	FGFR3 mutant receptor activation
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
eventOf	[Pathway:R-HSA-5655332] Signaling by FGFR3 in disease - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Pathway:R-HSA-1839130] Signaling by activated point mutants of FGFR3 - Homo sapiens [Pathway:R-HSA-2033515] t(4;14) translocations of FGFR3 - Homo sapiens [Pathway:R-HSA-8853334] Signaling by FGFR3 fusions in cancer - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:2045061] FGFR activation in skeletal disorders: too much of a good thing [LiteratureReference:2045065] Fibroblast growth factor receptors: lessons from the genes [LiteratureReference:2045066] Fibroblast growth factors and their receptors in cancer [LiteratureReference:2033245] High incidence of translocations t(11;14)(q13;q32) and t(4;14)(p16;q32) in patients with plasma cell malignancies [LiteratureReference:2033248] Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3 [LiteratureReference:2032925] Deregulated FGFR3 mutants in multiple myeloma cell lines with t(4;14): comparative analysis of Y373C, K650E and the novel G384D mutations [LiteratureReference:2033240] Expression of fibroblast growth factor and FGF-receptor family genes in human myeloma cells, including lines possessing t(4;14)(q16.3;q32. 3) and FGFR3 translocation [LiteratureReference:2033249] Mutation, SNP, and isoform analysis of fibroblast growth factor receptor 3 (FGFR3) in 150 newly diagnosed multiple myeloma patients [LiteratureReference:8853053] Transforming fusions of FGFR and TACC genes in human glioblastoma [LiteratureReference:8853033] The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma [LiteratureReference:8852986] Oncogenic FGFR3 gene fusions in bladder cancer [LiteratureReference:8852972] Identification of targetable FGFR gene fusions in diverse cancers [LiteratureReference:8852927] FGFR1/3 tyrosine kinase fusions define a unique molecular subtype of non-small cell lung cancer [LiteratureReference:8852989] Recurrent FGFR3-TACC3 fusion gene in nasopharyngeal carcinoma [LiteratureReference:8852962] Identification of recurrent FGFR3-TACC3 fusion oncogenes from lung adenocarcinoma [LiteratureReference:8852935] FGFR3-TACC3: A novel gene fusion in cervical cancer [LiteratureReference:8852916] Emergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumours
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	FGFR3 mutant receptor activation
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15 [InstanceEdit:8853855] Grose, Richard P, 2016-01-25
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2033514
summation	[Summation:5691451] The FGFR3 gene has been shown to be subject to activating mu...

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[Pathway:R-HSA-5655332] Signaling by FGFR3 in disease

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