Expression of NPPA (ANF)

Stable Identifier
Reaction [omitted]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Transcription of the NPPA (ANF) gene is stimulated by the action of a transcription factor complex that includes WWTR1 (TAZ), TBX5, and the PCAF (KAT2B) histone acetyltransferase (Murakami et al. 2005). Homeobox protein NKX-2.5 (NKX2-5), in cooperation with transcription factor GATA-4 (GATA4) and interacting partners homeodomain-interacting protein kinase 1 and 2 (HIPK1 and 2), acts as a transcriptional activator factor of NPPA in mice (Lee et al. 1998). Defects in NKX2-5 can cause diverse cardiac developmental disorders (Schott et al. 1998, Benson et al. 1999).

Literature References
PubMed ID Title Journal Year
9584153 The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression

Markham, BE, Jobe, SM, Shioi, T, Wiese, RJ, Izumo, S, Kasahara, H, Lee, Y

Mol. Cell. Biol. 1998
16332960 A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome

Murakami, M, Olson, EN, Nakagawa, O, Nakagawa, M

Proc Natl Acad Sci U S A 2005
9651244 Congenital heart disease caused by mutations in the transcription factor NKX2-5

Seidman, CE, Moak, JP, Basson, CT, Maron, BJ, Silberbach, GM, Pease, W, Seidman, JG, Schott, JJ, Benson, DW

Science 1998
10587520 Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways

Smalls, O, Zhang, Y, Watson, MS, Johnson, MC, Cottrill, C, Benson, DW, Kugler, JD, Riggs, S, Seidman, CE, Plowden, J, Silberbach, GM, Kavanaugh-McHugh, A, Seidman, JG

J. Clin. Invest. 1999
This event is regulated