Expression of NPPA (ANF)

Stable Identifier
R-HSA-2032800
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Expression of NPPA (ANF)
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Transcription of the NPPA (ANF) gene is stimulated by the action of a transcription factor complex that includes WWTR1 (TAZ), TBX5, and the PCAF (KAT2B) histone acetyltransferase (Murakami et al. 2005). Homeobox protein NKX-2.5 (NKX2-5), in cooperation with transcription factor GATA-4 (GATA4) and interacting partners homeodomain-interacting protein kinase 1 and 2 (HIPK1 and 2), acts as a transcriptional activator factor of NPPA in mice (Lee et al. 1998). Defects in NKX2-5 can cause diverse cardiac developmental disorders (Schott et al. 1998, Benson et al. 1999).
Literature References
PubMed ID Title Journal Year
9584153 The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression

Lee, Y, Shioi, T, Kasahara, H, Jobe, SM, Wiese, RJ, Markham, BE, Izumo, S

Mol. Cell. Biol. 1998
16332960 A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome

Murakami, M, Nakagawa, M, Olson, EN, Nakagawa, O

Proc Natl Acad Sci U S A 2005
9651244 Congenital heart disease caused by mutations in the transcription factor NKX2-5

Schott, JJ, Benson, DW, Basson, CT, Pease, W, Silberbach, GM, Moak, JP, Maron, BJ, Seidman, CE, Seidman, JG

Science 1998
10587520 Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways

Benson, DW, Silberbach, GM, Kavanaugh-McHugh, A, Cottrill, C, Zhang, Y, Riggs, S, Smalls, O, Johnson, MC, Watson, MS, Seidman, JG, Seidman, CE, Plowden, J, Kugler, JD

J. Clin. Invest. 1999
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
TBX5:WWTR1:PCAF [nucleoplasm] (Homo sapiens)
Regulator
NKX2-5:GATA4:HIPK1,2 [nucleoplasm] (Homo sapiens)
Authored
D'Eustachio, P  (2012-02-03)
Reviewed
Sudol, M  (2012-02-03)
Created
D'Eustachio, P  (2012-01-08)
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