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Schema
>
Pathway
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Entries
Physiological factors
Show undefined attributes
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authored
[InstanceEdit:5578800] Jassal, Bijay, 2014-06-02
created
[InstanceEdit:5578800] Jassal, Bijay, 2014-06-02
dbId
5578768
displayName
Physiological factors
edited
[InstanceEdit:5578800] Jassal, Bijay, 2014-06-02
eventOf
[Pathway:R-HSA-5576891] Cardiac conduction - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:5673483] regulation of cardiac conduction
hasDiagram
false
hasEHLD
false
hasEvent
[BlackBoxEvent:R-HSA-2032800] Expression of NPPA (ANF) - Homo sapiens
[Reaction:R-HSA-5578783] CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) - Homo sapiens
[Reaction:R-HSA-6784598] NPPA(124-151) binds NPR1 - Homo sapiens
[Reaction:R-HSA-5692408] NPR2 binds NPPC - Homo sapiens
[Reaction:R-HSA-9727567] CES1 hydrolyses sacubitril to sacubitrilat - Homo sapiens
[Reaction:R-HSA-9727607] MME:Zn2+ binds sacubitrilat - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2022-06-09
literatureReference
[LiteratureReference:6784601] Guanylyl cyclase/natriuretic peptide receptor-A signaling antagonizes phosphoinositide hydrolysis, Ca(2+) release, and activation of protein kinase C
maxDepth
2
modified
[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name
Physiological factors
orthologousEvent
[Pathway:R-DDI-5578768] Physiological factors - Dictyostelium discoideum
[Pathway:R-CEL-5578768] Physiological factors - Caenorhabditis elegans
[Pathway:R-DME-5578768] Physiological factors - Drosophila melanogaster
[Pathway:R-GGA-5578768] Physiological factors - Gallus gallus
[Pathway:R-XTR-5578768] Physiological factors - Xenopus tropicalis
[Pathway:R-DRE-5578768] Physiological factors - Danio rerio
[Pathway:R-SSC-5578768] Physiological factors - Sus scrofa
[Pathway:R-BTA-5578768] Physiological factors - Bos taurus
[Pathway:R-CFA-5578768] Physiological factors - Canis familiaris
[Pathway:R-RNO-5578768] Physiological factors - Rattus norvegicus
[Pathway:R-MMU-5578768] Physiological factors - Mus musculus
releaseDate
2015-12-15
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:6809173] Colotti, Gianni, 2015-11-09
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-5578768
summation
[Summation:6797411] Cardiovascular homeostasis can be regulated by natriuretic p...
updateTrackers
[UpdateTracker:9774770] Update Tracker - [Pathway:5578768] Physiological factors - v81:[addHasEvent]
Referrals
(updatedInstance)
[UpdateTracker:9774770] Update Tracker - [Pathway:5578768] Physiological factors - v81:[addHasEvent]
(hasEvent)
[Pathway:R-HSA-5576891] Cardiac conduction
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