Reactome | Dimerized phospho-IRF3 migrates to the nucleus

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Dimerized phospho-IRF3 migrates to the nucleus Show undefined attributes

category	transition
compartment	[Compartment:70101] cytosol [Compartment:13231] nuclear envelope [Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10041013
displayName	Dimerized phospho-IRF3 migrates to the nucleus
eventOf	[Pathway:R-MMU-1606341] IRF3 mediated activation of type 1 IFN - Mus musculus [Pathway:R-MMU-3270619] IRF3-mediated induction of type I IFN - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-3134883] Beta-catenin enhances association of IRF3 with CBP/p300 - Mus musculus
inferredFrom	[Reaction:R-HSA-2032396] Dimerized phospho-IRF3 migrates to the nucleus - Homo sapiens
input	[Complex:R-MMU-166272] p-T,4S-IRF3:p-T,4S-IRF3 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Dimerized phospho-IRF3 migrates to the nucleus
output	[Complex:R-MMU-177675] p-T,4S-IRF3:p-T,4S-IRF3 [nucleoplasm]
precedingEvent	[Reaction:R-MMU-2395992] p-T,4S-IRF3 is dimerized - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-2032396
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-MMU-3134883] Beta-catenin enhances association of IRF3 with CBP/p300
(hasEvent)	[Pathway:R-MMU-3270619] IRF3-mediated induction of type I IFN [Pathway:R-MMU-1606341] IRF3 mediated activation of type 1 IFN
(inferredTo)	[Reaction:R-HSA-2032396] Dimerized phospho-IRF3 migrates to the nucleus

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