Reactome | WWTR1 binds SMAD2/3:SMAD4 heterotrimer

Schema > Reaction > Entries

WWTR1 binds SMAD2/3:SMAD4 heterotrimer Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10385354
displayName	WWTR1 binds SMAD2/3:SMAD4 heterotrimer
eventOf	[Pathway:R-BTA-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-BTA-2106579] WWTR1:SMAD translocates to the nucleus - Bos taurus
inferredFrom	[Reaction:R-HSA-2031355] WWTR1 binds SMAD2/3:SMAD4 heterotrimer - Homo sapiens
input	[DefinedSet:R-BTA-171175] p-2S-SMAD2,3:SMAD4 [cytosol] [EntityWithAccessionedSequence:R-BTA-1629773] WWTR1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	WWTR1 binds SMAD2/3:SMAD4 heterotrimer
output	[Complex:R-BTA-2031357] WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol]
precedingEvent	[Reaction:R-BTA-170847] Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-2031355
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
(precedingEvent)	[BlackBoxEvent:R-BTA-2106579] WWTR1:SMAD translocates to the nucleus
(inferredTo)	[Reaction:R-HSA-2031355] WWTR1 binds SMAD2/3:SMAD4 heterotrimer

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