Reactome | WWTR1 binds SMAD2/3:SMAD4 heterotrimer

WWTR1 binds SMAD2/3:SMAD4 heterotrimer

Stable Identifier

R-HSA-2031355

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

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In the cytosol of human embryonic stem cells, WWTR1 (TAZ) binds heterotrimer composed of two R-SMADs (SMAD2 and/or SMAD3) and SMAD4. This interaction involves the C-terminus of WWTR1 (TAZ) and the MH1 domain of SMAD proteins.

Literature References

PubMed ID	Title	Journal	Year
18568018	TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal Varelas, X, Sakuma, R, Samavarchi-Tehrani, P, Peerani, R, Rao, BM, Dembowy, J, Yaffe, MB, Zandstra, PW, Wrana, JL	Nat Cell Biol	2008