Reactome | Tyrosine kinase inhibitors bind to overexpressed FGFR2 variants

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Tyrosine kinase inhibitors bind to overexpressed FGFR2 variants Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:2029991] Rothfels, K, 2012-01-05
crossReference	[DatabaseIdentifier:12020782] Mondo:0001056
dbId	2029992
disease	[Disease:1500576] breast cancer [Disease:1500689] cancer [Disease:1500687] stomach cancer
displayName	Tyrosine kinase inhibitors bind to overexpressed FGFR2 variants
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5654470] gain_of_function of Overexpressed FGFR2 homodimers [plasma membrane]
eventOf	[Pathway:R-HSA-2023837] Signaling by FGFR2 amplification mutants - Homo sapiens
input	[DefinedSet:R-HSA-2029963] Overexpressed FGFR2 homodimers [plasma membrane] 2 × [DefinedSet:R-ALL-2029965] Tyrosine kinase inhibitors of overexpressed FGFR2 [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:2023811] AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor [LiteratureReference:2023815] Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Tyrosine kinase inhibitors bind to overexpressed FGFR2 variants
output	[Complex:R-HSA-2029966] Overexpressed FGFR2:TKIs [plasma membrane]
precedingEvent	[Reaction:R-HSA-2029988] Dimerization of overexpressed FGFR2 - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2029992
summation	[Summation:2060746] Amplified FGFR2 has been shown to be a potential target for ...

Referrals

(hasEvent)

[Pathway:R-HSA-2023837] Signaling by FGFR2 amplification mutants

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