Reactome | Dimerization of overexpressed FGFR2

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Dimerization of overexpressed FGFR2 Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2029990] Rothfels, K, 2012-01-05
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	2029988
disease	[Disease:1500689] cancer
displayName	Dimerization of overexpressed FGFR2
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5654498] gain_of_function of Overexpressed FGFR2 [plasma membrane]
eventOf	[Pathway:R-HSA-2023837] Signaling by FGFR2 amplification mutants - Homo sapiens
followingEvent	[Reaction:R-HSA-2029989] Autocatalytic phosphorylation of overexpressed FGFR2 variants - Homo sapiens [Reaction:R-HSA-2029992] Tyrosine kinase inhibitors bind to overexpressed FGFR2 variants - Homo sapiens
input	2 × [DefinedSet:R-HSA-2029960] Overexpressed FGFR2 [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:2023815] Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets [LiteratureReference:2023814] Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform [LiteratureReference:2023811] AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor [LiteratureReference:2023821] FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival [LiteratureReference:2029817] Preferential alternative splicing in cancer generates a K-sam messenger RNA with higher transforming activity [LiteratureReference:2029811] Involvement of fibroblast growth factor receptor 2 isoform switching in mammary oncogenesis [LiteratureReference:2023825] Deletion of the carboxyl-terminal exons of K-sam/FGFR2 by short homology-mediated recombination, generating preferential expression of specific messenger RNAs [LiteratureReference:2060772] Transforming potential of alternatively spliced variants of fibroblast growth factor receptor 2 in human mammary epithelial cells [LiteratureReference:2060755] K-sam, an amplified gene in stomach cancer, is a member of the heparin-binding growth factor receptor genes
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Dimerization of overexpressed FGFR2
output	[DefinedSet:R-HSA-2029963] Overexpressed FGFR2 homodimers [plasma membrane]
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2029988
summation	[Summation:2029969] Overexpressed FGFR2 in gastric and breast cancer cells has b...

Referrals

(precedingEvent)	[Reaction:R-HSA-2029989] Autocatalytic phosphorylation of overexpressed FGFR2 variants [Reaction:R-HSA-2029992] Tyrosine kinase inhibitors bind to overexpressed FGFR2 variants
(hasEvent)	[Pathway:R-HSA-2023837] Signaling by FGFR2 amplification mutants

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