Reactome | Overexpressed FGFR2 homodimers [plasma membrane]

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Overexpressed FGFR2 homodimers [plasma membrane] Show undefined attributes

catalystActivities	[CatalystActivity:2029976] protein tyrosine kinase activity of Overexpressed FGFR2 homodimers [plasma membrane]
compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-2029966] Overexpressed FGFR2:TKIs [plasma membrane] - Homo sapiens [Complex:R-HSA-2067714] Overexpressed FGFR2 homodimers:GP369 [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-2029989] Autocatalytic phosphorylation of overexpressed FGFR2 variants - Homo sapiens [Reaction:R-HSA-2029992] Tyrosine kinase inhibitors bind to overexpressed FGFR2 variants - Homo sapiens [Reaction:R-HSA-2067713] GP369 inhibits activation of amplified FGFR2 signaling - Homo sapiens
created	[InstanceEdit:2029962] Rothfels, K, 2012-01-05
dbId	2029963
disease	[Disease:1500689] cancer [Disease:1500576] breast cancer [Disease:1500687] stomach cancer
displayName	Overexpressed FGFR2 homodimers [plasma membrane]
hasMember	[Complex:R-HSA-2029921] FGFR2b C3 variant dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-2029938] Overexpressed FGFR2 dimer [plasma membrane] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:2023815] Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets [LiteratureReference:2023814] Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform [LiteratureReference:2023811] AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor
modified	[InstanceEdit:2067722] Rothfels, K, 2012-01-25
name	Overexpressed FGFR2 homodimers
producedByEvent	[Reaction:R-HSA-2029988] Dimerization of overexpressed FGFR2 - Homo sapiens
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-2029963

Referrals

(hasComponent)	[Complex:R-HSA-2067714] Overexpressed FGFR2 homodimers:GP369 [plasma membrane] [Complex:R-HSA-2029966] Overexpressed FGFR2:TKIs [plasma membrane]
(input)	[Reaction:R-HSA-2067713] GP369 inhibits activation of amplified FGFR2 signaling [Reaction:R-HSA-2029989] Autocatalytic phosphorylation of overexpressed FGFR2 variants [Reaction:R-HSA-2029992] Tyrosine kinase inhibitors bind to overexpressed FGFR2 variants
(physicalEntity)	[CatalystActivity:2029976] protein tyrosine kinase activity of Overexpressed FGFR2 homodimers [plasma membrane]
(output)	[Reaction:R-HSA-2029988] Dimerization of overexpressed FGFR2
(diseaseEntity)	[EntityFunctionalStatus:5654470] gain_of_function of Overexpressed FGFR2 homodimers [plasma membrane]

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