Reactome | FGFR2 ligand-independent mutants [plasma membrane]

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FGFR2 ligand-independent mutants [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-HSA-2029983] Dimerization of FGFR2 ligand-independent mutants - Homo sapiens [Reaction:R-HSA-2029983] Dimerization of FGFR2 ligand-independent mutants - Homo sapiens
created	[InstanceEdit:2029954] Rothfels, K, 2012-01-05
crossReference	[DatabaseIdentifier:12020828] Mondo:0005497
dbId	2029955
disease	[Disease:1500689] cancer [Disease:2032940] bone development disease
displayName	FGFR2 ligand-independent mutants [plasma membrane]
hasCandidate	[EntityWithAccessionedSequence:R-HSA-2029886] FGFR2c S372C [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2029881] FGFR2c Y375C [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1637924] FGFR2b S373C [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1637931] FGFR2b Y376C [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1637929] FGFR2 W290C [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1637908] FGFR2 L764Hfs*4 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9667332] FGFR2b C382R [plasma membrane] - Homo sapiens
hasMember	[EntityWithAccessionedSequence:R-HSA-1637920] FGFR2 S267P [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2029883] FGFR2c W290G [plasma membrane] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:1637891] Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes
maxDepth	2
modified	[InstanceEdit:9667353] Rothfels, Karen, 2019-11-11
name	FGFR2 ligand-independent mutants
schemaClass	CandidateSet
species	[Species:48887] Homo sapiens
stId	R-HSA-2029955
updateTrackers	[UpdateTracker:9900958] Update Tracker - [CandidateSet:2029955] FGFR2 ligand-independent mutants [plasma membrane] - v71:[addHasCandidate]

Referrals

(updatedInstance)	[UpdateTracker:9900958] Update Tracker - [CandidateSet:2029955] FGFR2 ligand-independent mutants [plasma membrane] - v71:[addHasCandidate]
(input)	[Reaction:R-HSA-2029983] Dimerization of FGFR2 ligand-independent mutants
(diseaseEntity)	[EntityFunctionalStatus:5654488] gain_of_function of FGFR2 ligand-independent mutants [plasma membrane]

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