Reactome | Dimerization of FGFR2 ligand-independent mutants

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Dimerization of FGFR2 ligand-independent mutants Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2029982] Rothfels, K, 2012-01-05
dbId	2029983
disease	[Disease:1500689] cancer
displayName	Dimerization of FGFR2 ligand-independent mutants
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5654488] gain_of_function of FGFR2 ligand-independent mutants [plasma membrane]
eventOf	[Pathway:R-HSA-2033519] Activated point mutants of FGFR2 - Homo sapiens
followingEvent	[Reaction:R-HSA-2029984] Autocatalytic phosphorylation of FGFR2 ligand-independent mutants - Homo sapiens
input	2 × [CandidateSet:R-HSA-2029955] FGFR2 ligand-independent mutants [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1637891] Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes [LiteratureReference:2029807] FGFR2 mutations are rare across histologic subtypes of ovarian cancer [LiteratureReference:2032931] Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation [LiteratureReference:2018771] Patterns of somatic mutation in human cancer genomes [LiteratureReference:1614272] Somatic mutations of the protein kinase gene family in human lung cancer [LiteratureReference:1637882] Drug-sensitive FGFR2 mutations in endometrial carcinoma [LiteratureReference:2029801] Apert syndrome mutations in fibroblast growth factor receptor 2 exhibit increased affinity for FGF ligand [LiteratureReference:2029799] Activating mutations in the extracellular domain of the fibroblast growth factor receptor 2 function by disruption of the disulfide bond in the third immunoglobulin-like domain [LiteratureReference:2032923] Constitutive receptor activation by Crouzon syndrome mutations in fibroblast growth factor receptor (FGFR)2 and FGFR2/Neu chimeras [LiteratureReference:2018765] Constitutive activation of fibroblast growth factor receptor 3 by mutations responsible for the lethal skeletal dysplasia thanatophoric dysplasia type I [LiteratureReference:2045070] Ligand-independent activation of fibroblast growth factor receptors by point mutations in the extracellular, transmembrane, and kinase domains
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Dimerization of FGFR2 ligand-independent mutants
output	[CandidateSet:R-HSA-2029952] FGFR2 ligand-independent mutant dimers [plasma membrane]
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2029983
summation	[Summation:2060765] Point mutations in FGFR2 that are thought to promote ligand-...

Referrals

(precedingEvent)	[Reaction:R-HSA-2029984] Autocatalytic phosphorylation of FGFR2 ligand-independent mutants
(hasEvent)	[Pathway:R-HSA-2033519] Activated point mutants of FGFR2

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