Activation of RAC1 by CRKII:DOCK180:ELMO

Stable Identifier
R-HSA-2029467
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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General
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RAC1 is activated from inactive GDP-bound state to active GTP-bound form by the GEF activity of DOCK180:ELMO complex.

Literature References
PubMed ID Title Journal Year
17308335 Role of CrkII in Fcgamma receptor-mediated phagocytosis

Lee, WL, Cosio, G, Ireton, K, Grinstein, S

J Biol Chem 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created