Activation of RAC1 by CRKII:DOCK180:ELMO

Stable Identifier
R-HSA-2029467
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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Activation of RAC1 by CRKII:DOCK180:ELMO
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RAC1 is activated from inactive GDP-bound state to active GTP-bound form by the GEF activity of DOCK180:ELMO complex.
Literature References
PubMed ID Title Journal Year
17308335 Role of CrkII in Fcgamma receptor-mediated phagocytosis

Ireton, K, Lee, WL, Grinstein, S, Cosio, G

J Biol Chem 2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane]

Physical Entity
CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
Activation of RAC1 by CRKII:DOCK180:ELMO (Bos taurus)
Activation of RAC1 by CRKII:DOCK180:ELMO (Canis familiaris)
Activation of RAC1 by CRKII:DOCK180:ELMO (Gallus gallus)
Activation of RAC1 by CRKII:DOCK180:ELMO (Mus musculus)
Activation of RAC1 by CRKII:DOCK180:ELMO (Rattus norvegicus)
Activation of RAC1 by CRKII:DOCK180:ELMO (Sus scrofa)
Authored
Garapati, P V  (2012-01-04)
Reviewed
Rosales, C  (2012-05-15)
Created
Garapati, P V  (2012-01-04)
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