Activation of RAC1 by CRKII:DOCK180:ELMO

Stable Identifier
R-HSA-2029467
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

RAC1 is activated from inactive GDP-bound state to active GTP-bound form by the GEF activity of DOCK180:ELMO complex.

Literature References
PubMed ID Title Journal Year
17308335 Role of CrkII in Fcgamma receptor-mediated phagocytosis

Ireton, K, Lee, WL, Grinstein, S, Cosio, G

J Biol Chem 2007
Participants
Participates
Catalyst Activity

guanyl-nucleotide exchange factor activity of CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
Cite Us!