Activation of RAC1 by CRKII:DOCK180:ELMO

Stable Identifier
R-HSA-2029467
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
Locations in the PathwayBrowser
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Activation of RAC1 by CRKII:DOCK180:ELMO
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RAC1 is activated from inactive GDP-bound state to active GTP-bound form by the GEF activity of DOCK180:ELMO complex.

Literature References
PubMed ID Title Journal Year
17308335 Role of CrkII in Fcgamma receptor-mediated phagocytosis

Lee, WL, Cosio, G, Ireton, K, Grinstein, S

J Biol Chem 2007
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane]
Physical Entity
CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane]
Activity
guanyl-nucleotide exchange factor activity (0005085)
Orthologous Events
Activation of RAC1 by CRKII:DOCK180:ELMO (Danio rerio)
Activation of RAC1 by CRKII:DOCK180:ELMO (Gallus gallus)
Activation of RAC1 by CRKII:DOCK180:ELMO (Mus musculus)
Activation of RAC1 by CRKII:DOCK180:ELMO (Rattus norvegicus)
Activation of RAC1 by CRKII:DOCK180:ELMO (Sus scrofa)
Activation of RAC1 by CRKII:DOCK180:ELMO (Xenopus tropicalis)
Authored
Garapati, P V  (2012-01-04)
Reviewed
Rosales, C  (2012-05-15)
Created
Garapati, P V  (2012-01-04)
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