Reactome | PI3K phosphorylates PIP2 to PIP3

PI3K phosphorylates PIP2 to PIP3

Stable Identifier

R-HSA-2029271

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane, extracellular region

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Activated PI3K phosphorylates phosphatidylinositol (PI) 4-phosphate and PI 4,5-bisphosphate (PIP2) to generate PI 3,4-bisphosphate and PI 3,4,5-triphosphate (PIP3) and these second messengers recruit other signaling proteins containing plecstrin homology (PH) domain. PIP3 rapidly accumulates at sites of phagocytosis and disappears after the phagosome has been sealed off from the plasma membrane.

Literature References

PubMed ID	Title	Journal	Year
11425868	Restricted accumulation of phosphatidylinositol 3-kinase products in a plasmalemmal subdomain during Fc gamma receptor-mediated phagocytosis Marshall, JG, Booth, JW, Stambolic, V, Mak, T, Balla, T, Schreiber, AD, Meyer, T, Grinstein, S	J Cell Biol	2001
15809313	Phosphatidylinositol-4,5-bisphosphate hydrolysis directs actin remodeling during phagocytosis Scott, CC, Dobson, W, Botelho, RJ, Coady-Osberg, N, Chavrier, P, Knecht, DA, Heath, C, Stahl, P, Grinstein, S	J Cell Biol	2005
12660731	The role of PI3K in immune cells Koyasu, S	Nat Immunol	2003