PI3K phosphorylates PIP2 to PIP3

Stable Identifier
R-HSA-2029271
Type
Reaction [transition]
Species
Homo sapiens
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Activated PI3K phosphorylates phosphatidylinositol (PI) 4-phosphate and PI 4,5-bisphosphate (PIP2) to generate PI 3,4-bisphosphate and PI 3,4,5-triphosphate (PIP3) and these second messengers recruit other signaling proteins containing plecstrin homology (PH) domain. PIP3 rapidly accumulates at sites of phagocytosis and disappears after the phagosome has been sealed off from the plasma membrane.

Literature References
PubMed ID Title Journal Year
11425868 Restricted accumulation of phosphatidylinositol 3-kinase products in a plasmalemmal subdomain during Fc gamma receptor-mediated phagocytosis

Marshall, JG, Booth, JW, Stambolic, V, Mak, T, Balla, T, Schreiber, AD, Meyer, T, Grinstein, S

J Cell Biol 2001
15809313 Phosphatidylinositol-4,5-bisphosphate hydrolysis directs actin remodeling during phagocytosis

Scott, CC, Dobson, W, Botelho, RJ, Coady-Osberg, N, Chavrier, P, Knecht, DA, Heath, C, Stahl, P, Grinstein, S

J Cell Biol 2005
12660731 The role of PI3K in immune cells

Koyasu, S

Nat Immunol 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol-4,5-bisphosphate 3-kinase activity of PI3K:p-6Y-SYK [plasma membrane]
Physical Entity
Activity
Orthologous Events
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