Activated PI3K phosphorylates phosphatidylinositol (PI) 4-phosphate and PI 4,5-bisphosphate (PIP2) to generate PI 3,4-bisphosphate and PI 3,4,5-triphosphate (PIP3) and these second messengers recruit other signaling proteins containing plecstrin homology (PH) domain. PIP3 rapidly accumulates at sites of phagocytosis and disappears after the phagosome has been sealed off from the plasma membrane.
Botelho, RJ, Dobson, W, Knecht, DA, Grinstein, S, Coady-Osberg, N, Heath, C, Stahl, P, Chavrier, P, Scott, CC
Balla, T, Marshall, JG, Meyer, T, Stambolic, V, Mak, T, Grinstein, S, Booth, JW, Schreiber, AD
Koyasu, S
phosphatidylinositol-4,5-bisphosphate 3-kinase activity of PI3K:p-6Y-SYK [plasma membrane]
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