Phosphorylation and activation of PLCG

Stable Identifier
R-HSA-2029268
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation and activation of PLCG
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
PLCG is tyrosine phosphorylated by either SYK or Src kinases on three tyrosine residues and this phosphorylation enhances the activity of PLCG. Although maximal activation requires binding of PLCG to PIP3 with its plecstrin homology (PH) domain.
Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane]

Physical Entity
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Phosphorylation and activation of PLCG (Bos taurus)
Phosphorylation and activation of PLCG (Canis familiaris)
Phosphorylation and activation of PLCG (Gallus gallus)
Phosphorylation and activation of PLCG (Mus musculus)
Phosphorylation and activation of PLCG (Rattus norvegicus)
Phosphorylation and activation of PLCG (Sus scrofa)
Authored
Garapati, P V  (2012-01-04)
Reviewed
Rosales, C  (2012-05-15)
Created
Garapati, P V  (2012-01-04)
Cite Us!