Phosphorylation and activation of PLCG

Stable Identifier
R-HSA-2029268
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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General
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PLCG is tyrosine phosphorylated by either SYK or Src kinases on three tyrosine residues and this phosphorylation enhances the activity of PLCG. Although maximal activation requires binding of PLCG to PIP3 with its plecstrin homology (PH) domain.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created