As inferred from mouse (Okamura et al. 2000), calcineurin dephosphorylates NFATC2 at 13 serine residues (Batiuk et al. 1997, Kim et al. 2000). B lymphocytes also contain NFATC2 and NFATC3 which are inferred to undergo dephosphorylation at homologous serines. Dephosphorylation of NFATs exposes a nuclear localization signal which cause NFATs to be imported into the nucleus (Kim et al. 2000). In mouse, Calcineurin is observed to also transit into the nucleus in a complex with NFATs and may remain associated (Shibasaki et al. 1996).
Okamura, H, Aramburu, J, García-Rodríguez, C, Viola, JP, Raghavan, A, Tahiliani, M, Zhang, X, Qin, J, Hogan, PG, Rao, A
Beals, CR, Clipstone, NA, Ho, SN, Crabtree, GR
Shibasaki, F, Price, ER, Milan, D, McKeon, F
Park, J, Yaseen, NR, Hogan, PG, Rao, A, Sharma, S
Batiuk, TD, Kung, L, Halloran, PF
Kim, LJ, Ferguson, HA, Seto, AG, Goodrich, JA
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