Calcineurin dephosphorylates NFATC1,2,3

Stable Identifier
R-HSA-2025882
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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Calcineurin dephosphorylates NFATC1,2,3
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As inferred from mouse (Okamura et al. 2000), calcineurin dephosphorylates NFATC2 at 13 serine residues (Batiuk et al. 1997, Kim et al. 2000). B lymphocytes also contain NFATC2 and NFATC3 which are inferred to undergo dephosphorylation at homologous serines. Dephosphorylation of NFATs exposes a nuclear localization signal which cause NFATs to be imported into the nucleus (Kim et al. 2000). In mouse, Calcineurin is observed to also transit into the nucleus in a complex with NFATs and may remain associated (Shibasaki et al. 1996).

Literature References
PubMed ID Title Journal Year
9106655 Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction

Clipstone, NA, Ho, SN, Crabtree, GR, Beals, CR

Genes Dev 1997
11030334 Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity

Zhang, X, Rao, A, Viola, JP, Okamura, H, Hogan, PG, Tahiliani, M, Aramburu, J, García-Rodríguez, C, Qin, J, Raghavan, A

Mol Cell 2000
8684469 Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4

Price, ER, Shibasaki, F, Milan, D, McKeon, F

Nature 1996
7657645 Phosphorylation of the transcription factor NFATp inhibits its DNA binding activity in cyclosporin A-treated human B and T cells

Rao, A, Sharma, S, Hogan, PG, Yaseen, NR, Park, J

J Biol Chem 1995
9312192 Evidence that calcineurin is rate-limiting for primary human lymphocyte activation

Batiuk, TD, Kung, L, Halloran, PF

J Clin Invest 1997
11231878 Characterization of DNA binding, transcriptional activation, and regulated nuclear association of recombinant human NFATp

Goodrich, JA, Kim, LJ, Seto, AG, Ferguson, HA

BMC Immunol 2000
Participants
Input
Output
Participates
as an event of
Catalyst Activity

calcium-dependent protein serine/threonine phosphatase activity of Calcineurin:p-NFATC1,2,3 [cytosol]

Physical Entity
Calcineurin:p-NFATC1,2,3 [cytosol] (Homo sapiens)
Activity
calcium-dependent protein serine/threonine phosphatase activity (GO:0004723)
This event is regulated
Negatively by
Regulator
FKBP1A:tacrolimus [cytosol] (Homo sapiens)
Regulator
Cyclophilin A:Cyclosporin A [cytosol] (Homo sapiens)
Inferred From
Calcineurin Dephosphorylates Nfatc2 (Mus musculus)
Authored
May, B  (2011-12-11)
Reviewed
Wienands, J  (2012-02-12)
Created
May, B  (2011-12-20)
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