Calcineurin dephosphorylates NFATC1,2,3

Stable Identifier
R-HSA-2025882
Type
Reaction [omitted]
Species
Homo sapiens
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As inferred from mouse (Okamura et al. 2000), calcineurin dephosphorylates NFATC2 at 13 serine residues (Batiuk et al. 1997, Kim et al. 2000). B lymphocytes also contain NFATC2 and NFATC3 which are inferred to undergo dephosphorylation at homologous serines. Dephosphorylation of NFATs exposes a nuclear localization signal which cause NFATs to be imported into the nucleus (Kim et al. 2000). In mouse, Calcineurin is observed to also transit into the nucleus in a complex with NFATs and may remain associated (Shibasaki et al. 1996).

Literature References
PubMed ID Title Journal Year
11030334 Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity

Okamura, H, Aramburu, J, García-Rodríguez, C, Viola, JP, Raghavan, A, Tahiliani, M, Zhang, X, Qin, J, Hogan, PG, Rao, A

Mol Cell 2000
9106655 Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction

Beals, CR, Clipstone, NA, Ho, SN, Crabtree, GR

Genes Dev 1997
8684469 Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4

Shibasaki, F, Price, ER, Milan, D, McKeon, F

Nature 1996
7657645 Phosphorylation of the transcription factor NFATp inhibits its DNA binding activity in cyclosporin A-treated human B and T cells

Park, J, Yaseen, NR, Hogan, PG, Rao, A, Sharma, S

J Biol Chem 1995
9312192 Evidence that calcineurin is rate-limiting for primary human lymphocyte activation

Batiuk, TD, Kung, L, Halloran, PF

J Clin Invest 1997
11231878 Characterization of DNA binding, transcriptional activation, and regulated nuclear association of recombinant human NFATp

Kim, LJ, Ferguson, HA, Seto, AG, Goodrich, JA

BMC Immunol 2000
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Catalyst Activity
Title
calcium-dependent protein serine/threonine phosphatase activity of Calcineurin:Phosphorylated NFATC1,2,3 [cytosol]
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