Calcineurin dephosphorylates NFATC1,2,3

Stable Identifier
Reaction [omitted]
Homo sapiens
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As inferred from mouse (Okamura et al. 2000), calcineurin dephosphorylates NFATC2 at 13 serine residues (Batiuk et al. 1997, Kim et al. 2000). B lymphocytes also contain NFATC2 and NFATC3 which are inferred to undergo dephosphorylation at homologous serines. Dephosphorylation of NFATs exposes a nuclear localization signal which cause NFATs to be imported into the nucleus (Kim et al. 2000). In mouse, Calcineurin is observed to also transit into the nucleus in a complex with NFATs and may remain associated (Shibasaki et al. 1996).

Literature References
PubMed ID Title Journal Year
9106655 Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction

Clipstone, NA, Ho, SN, Crabtree, GR, Beals, CR

Genes Dev 1997
11030334 Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity

Zhang, X, Rao, A, Viola, JP, Okamura, H, Hogan, PG, Tahiliani, M, Aramburu, J, García-Rodríguez, C, Qin, J, Raghavan, A

Mol Cell 2000
8684469 Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4

Price, ER, Shibasaki, F, Milan, D, McKeon, F

Nature 1996
7657645 Phosphorylation of the transcription factor NFATp inhibits its DNA binding activity in cyclosporin A-treated human B and T cells

Rao, A, Sharma, S, Hogan, PG, Yaseen, NR, Park, J

J Biol Chem 1995
9312192 Evidence that calcineurin is rate-limiting for primary human lymphocyte activation

Batiuk, TD, Kung, L, Halloran, PF

J Clin Invest 1997
11231878 Characterization of DNA binding, transcriptional activation, and regulated nuclear association of recombinant human NFATp

Goodrich, JA, Kim, LJ, Seto, AG, Ferguson, HA

BMC Immunol 2000
Catalyst Activity

calcium-dependent protein serine/threonine phosphatase activity of Calcineurin:p-NFATC1,2,3 [cytosol]

This event is regulated
Inferred From
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