As inferred from mouse (Okamura et al. 2000), calcineurin dephosphorylates NFATC2 at 13 serine residues (Batiuk et al. 1997, Kim et al. 2000). B lymphocytes also contain NFATC2 and NFATC3 which are inferred to undergo dephosphorylation at homologous serines. Dephosphorylation of NFATs exposes a nuclear localization signal which cause NFATs to be imported into the nucleus (Kim et al. 2000). In mouse, Calcineurin is observed to also transit into the nucleus in a complex with NFATs and may remain associated (Shibasaki et al. 1996).
Clipstone, NA, Ho, SN, Crabtree, GR, Beals, CR
Zhang, X, Rao, A, Viola, JP, Okamura, H, Hogan, PG, Tahiliani, M, Aramburu, J, García-Rodríguez, C, Qin, J, Raghavan, A
Price, ER, Shibasaki, F, Milan, D, McKeon, F
Rao, A, Sharma, S, Hogan, PG, Yaseen, NR, Park, J
Batiuk, TD, Kung, L, Halloran, PF
Goodrich, JA, Kim, LJ, Seto, AG, Ferguson, HA
calcium-dependent protein serine/threonine phosphatase activity of Calcineurin:p-NFATC1,2,3 [cytosol]
© 2023 Reactome