NF-kB is sequestered in the cytosol of unstimulated cells th...

created [InstanceEdit:202550] Garapati, P V, 2007-11-01 14:13:20
dbId 202540
displayName NF-kB is sequestered in the cytosol of unstimulated cells th...
literatureReference
modified [InstanceEdit:5609917] Garapati, P V, 2014-07-18
schemaClass Summation
text NF-kB is sequestered in the cytosol of unstimulated cells through the interactions with a class of inhibitor proteins, called IkBs, which mask the nuclear localization signal (NLS) of NF-kB and prevent its nuclear translocation. A key event in NF-kB activation involves phosphorylation of IkB (at sites equivalent to Ser32 and Ser36 of IkB-alpha or Ser19 and Ser22 of IkB-beta) by IKK. The phosphorylated IkB-alpha is recognized by the E3 ligase complex and targeted for ubiquitin-mediated proteasomal degradation, releasing the NF-kB dimer p50/p65 into the nucleus to turn on target genes. (Karin & Ben-Neriah 2000)
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